The collaborative efforts of the Derbyshire and Haystead labs reveal that compounds that bind to Hsp90 represent a class of molecules that inhibit both blood- and liver-stage Plasmodium parasites.
The Franz Lab and collaborators explored the antibacterial mechanism of PcephPT, a prodrug of the antimicrobial chelator pyrithione. Graduate students Jacqueline Zaengle-Barone and Abigail Jackson and former grad student David Besse found that PcephPT has an unconventional mode of actio
A Departmental Collaboration is lighting up MRIs! Junu Bae of the Wang Lab and Zijian Zhou of the Warren Lab have developed chemical tags that attach to molecules, making them light up under MRI!
Professors David Beratan and Peng Zhang, with collaborators at NYU and ASU, have designed, built, and demonstrated current splitters and charge-transport junctions based on self-assembling nucleic acids. These constructs promise to expand the functionality of self-assembling bio-inspired electron
The Malcolmson lab has demonstrated that olefins may act as alkylating agents for the enantioselective intermolecular addition of enol-type nucleophiles under Pd catalysis.
The high temperatures and intense UV irradiation of the early earth made DNA particularly susceptible to damage. Beratan’s group used theory, modeling, and simulation to explore the mechanism of photochemical repair of damaged DNA by the enzyme photolyases.
The de novo design of a protein capable of binding a cofactor in a unique orientation is a challenging problem because a range of structurally similar, yet different, complexes are often formed. Now, a team led by former graduate student Nick Polizzi and by Professors David N.
The Malcolmson lab has reported a new class of reagents, 2-azadienes, for the catalytic enantioselective construction of chiral amines. The 2-azadienes demonstrate reverse polarity (umpolung) of an enamine, facilitating catalytic addition of a nucleophile to its N-b-carbon and subsequent stereos
Biology is well known to manipulate energy using proton-coupled electron transfer and phosphorylation reactions. It was found recently that energy conversion can also occur via a new class of reactions, known as electron bifurcation reactions.