Researchers in the Franz lab have built a peptide that binds one kind of metal ion with greater ease if it binds a different type of metal ion first. This unique example of cooperative, heterometallic allostery in a biologically compatible construct suggests the possibility of designing conditionally active metal-binding agents that could respond to dynamic changes in cellular metal status. Read more here: http://pubs.rsc.org/en/content/articlelanding/2015/SC/C5SC00602C#!divAbstract