Hong Lab Opens New Avenues for Drug Discovery and Mechanistic Studies

4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (1)

Hyejin Lee and others in the Hong lab have successfully achieved an asymmetric total synthesis of 4,9,10-trihydroxyguaia-11(13)en-12,6-olide (1), a naturally occurring guaianolide with intriguing biological potential. This 20-step synthetic route has uncovered exciting new anticancer activity of the natural product against aggressive childhood tumors, opening new avenues for drug discovery and mechanistic studies. Learn more about their recent discoveries in an ACS Central Science article here.