GGTDTC, a copper prochelator of dithiocarbamate was developed to release dithiocarbamate (DTC) in cancer expressing gamma-glutamyl transferase enzyme. Upon release DTC is free to bind to Cu to form toxic Cu(DTC)2 .
GGTDTC, a copper prochelator of dithiocarbamate was developed to release dithiocarbamate (DTC) in cancer expressing gamma-glutamyl transferase enzyme. Upon release DTC is free to bind to Cu to form toxic Cu(DTC)2 .
The Charbonneau lab is bringing together researchers from industry and academia to develop a tool for automatizing protein crystal recognition. Scientists came together to collect half a million images of protein crystallization experiments into a database that can specify which of these protein
Building upon their initial work illustrating the use of 2-azadienes for the enantioselective synthesis of challenging amine scaffolds, the Malcolmson lab has now reported that these reagents may engage in reductive couplings with imines for the synthesis of anti-1,2-diamines. The Cu-ca
The collaborative efforts of the Derbyshire and Haystead labs reveal that compounds that bind to Hsp90 represent a class of molecules that inhibit both blood- and liver-stage Plasmodium parasites.
The Franz Lab and collaborators explored the antibacterial mechanism of PcephPT, a prodrug of the antimicrobial chelator pyrithione. Graduate students Jacqueline Zaengle-Barone and Abigail Jackson and former grad student David Besse found that PcephPT has an unconventional mode of actio
A Departmental Collaboration is lighting up MRIs! Junu Bae of the Wang Lab and Zijian Zhou of the Warren Lab have developed chemical tags that attach to molecules, making them light up under MRI!
Professors David Beratan and Peng Zhang, with collaborators at NYU and ASU, have designed, built, and demonstrated current splitters and charge-transport junctions based on self-assembling nucleic acids. These constructs promise to expand the functionality of self-assembling bio-inspired electron
The Malcolmson lab has demonstrated that olefins may act as alkylating agents for the enantioselective intermolecular addition of enol-type nucleophiles under Pd catalysis.
The high temperatures and intense UV irradiation of the early earth made DNA particularly susceptible to damage. Beratan’s group used theory, modeling, and simulation to explore the mechanism of photochemical repair of damaged DNA by the enzyme photolyases.
