The Malcolmson lab has recently shown that gem-difluoroazadienes can serve as a novel building block for the synthesis of chiral alpha-trifluoromethyl amines via the vicinal fluoro-functionalization of its alkene.

The Hargrove Lab has created a general, high throughput technique for screening small molecule probes against different RNA targets using a fluorescence indicator displacement (FID) assay. Learn more about their fast and convenient method to simultaneously evaluate small molecule libraries agains

Graduate student Meredith Barbee and co-workers in the Craig lab and at Texas State have used a mixture of classical physical organic methodology and contemporary single molecule spectroscopy to tease out mechanistic details of a reaction occurring under large mechanical forces. Their

Agostino Migliore, Darius Teo and additional members of the Beratan Lab, with collaborators at USC, take an important step towards understanding intracellular redox signaling at the core of DNA repair and replication processes.

The static correlation error inherent in commonly used density functional approximations (DFAs) has seriously hindered the application of density functional theory (DFT) to strongly correlated systems.

While the majority of small molecule chemical probes and drugs to date modulate the action of proteins, the Hargrove Lab is searching for small molecules that selectively engage binding pockets of RNA.

The enantioselective and intermolecular addition of nucleophiles to internal olefins is a challenging process due to the typically low reactivity of these substrates.

Non-coding RNAs have been identified that are essential for cellular regulation and that are misregulated in disease; however, the development of tools to study these RNAs has been challenging.

GGTDTC, a copper prochelator of dithiocarbamate was developed to release dithiocarbamate (DTC) in cancer expressing gamma-glutamyl transferase enzyme. Upon release DTC is free to bind to Cu to form toxic Cu(DTC)₂ .

The Charbonneau lab is bringing together researchers from industry and academia to develop a tool for automatizing protein crystal recognition.  Scientists came together to collect half a million images of protein crystallization experiments into a database that can specify which of these protein