Research

Research + Discoveries

Small Molecule Inhibitors Target a Key Enzyme in Lipid A Biosynthesis

A team led by Professors Jiyong Hong and Pei Zhou has reported the molecular structure of LpxH in complex with a sulfonyl piperazine inhibitor and the identification of small molecule LpxH inhibitors with improved activity. These findings will facilitate structure-based ligand design for LpxH and help development of novel antibiotics targeting emerging multidrug-resistant nosocomial Gram-negative pathogens.  Read more about their discovery in Proceedings of the National Academy of Sciences, USA, available here.

Hong PNAS