Research + Discoveries

Small Molecule Drug May Prevent Chemotherapy Resistance

A team led by Professors Jiyong Hong and Pei Zhou has discovered a small molecule drug that can stop cancer cells from becoming resistant to chemotherapy. The new compound, which was tested in an animal model of melanoma, could serve as a powerful adjuvant to make current chemotherapies more effective. It works by thwarting cancer’s ability to survive, evolve, and adapt to the onslaught of DNA damage wrought by traditional chemotherapy drugs like cisplatin.  Read more about their discovery in the June 6 edition of Cell

Structure of the complex containing Rev1 and JH-RE-06. The two copies of the Rev1 protein are shown in dark and light blue, while the small molecule JH-RE-06 wedged in between is shown in bright pink.  Credit to Prof. Pei Zhou