Research + Discoveries

Malcolmson Lab Develops Enantioselective Alkylations of Enolates with Dienes

The Malcolmson lab has demonstrated that internal dienes may undergo regio- and enantioselective additions of enolate pronuclephiles. The transformations are promoted by Pd(PHOX) and Bronsted acid co-catalysts and deliver numerous products bearing 1,2-disubstituted olefins and a variety of alkyl groups at the stereogenic carbon. Read more about this research here in Chemical Science.