Research + Discoveries

Hargrove Lab Discovers Distinctive Properties of RNA-targeted Chemical Probes

The Hargrove Lab compared bioactive ligands that target RNA to current FDA-approved drugs, nearly all of which target proteins. With the help of the Beratan Lab, they identified key differences in physical, structural, and spatial properties that distinguish RNA-targeted bioactive ligands. These unique insights are expected to facilitate the selection and synthesis of RNA-targeted libraries with the goal of efficiently identifying selective small molecule ligands for therapeutically relevant RNAs.  Read more about this exciting research in Angewandte Chemie International's September 18 issue and on Duke Today!