Research + Discoveries

  • Malcolmson Lab Illustrates Enantioselective Hydroamination of Internal Dienes

    The enantioselective and intermolecular addition of nucleophiles to internal olefins is a challenging process due to the typically low reactivity of these substrates. Hydroaminations of 1,4-disubstituted dienes present further challenges as several product regioisomers may be obtained and reactions tend to be reversible, leading to erosion of enantiopurity of products over time. The Malcolmson lab has now demonstrated that Pd–PHOX catalysts facilitate the regio- and enantioselective hydroamination of internal dienes with aliphatic amines and anilines.

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  • Hargrove Lab Hopes to Expedite the Discovery of RNA-targeted Ligands

    Non-coding RNAs have been identified that are essential for cellular regulation and that are misregulated in disease; however, the development of tools to study these RNAs has been challenging.

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  • Franz Lab Combating Prostate Cancer One Metal at a Time

    GGTDTC, a copper prochelator of dithiocarbamate was developed to release dithiocarbamate (DTC) in cancer expressing gamma-glutamyl transferase enzyme. Upon release DTC is free to bind to Cu to form toxic Cu(DTC)2 . GGTDTC was found to selectively release diethyldithiocarbamate only in prostate cancer cells with measurable gamma-glutamyl transferase activity.  These findings underscore a new strategy to leverage the amplified copper metabolism of prostate cancer by conditional activation of a metal‐binding pharmacophore.

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  • Charbonneau Lab Using A.I. to Recognize Crystals in Protein Crystallization Experiments

    The Charbonneau lab is bringing together researchers from industry and academia to develop a tool for automatizing protein crystal recognition.  Scientists came together to collect half a million images of protein crystallization experiments into a database that can specify which of these protein cocktails led to crystallization, based on human evaluation. The team then worked with a group led by Vincent Vanhoucke from Google Brain to apply the latest in artificial intelligence to help identify crystals in the images. Read more on the

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  • Malcolmson Lab Demonstrates Reductive Coupling Strategy for 1,2-Diamine Synthesis

    Building upon their initial work illustrating the use of 2-azadienes for the enantioselective synthesis of challenging amine scaffolds, the Malcolmson lab has now reported that these reagents may engage in reductive couplings with imines for the synthesis of anti-1,2-diamines.  The Cu-catalyzed process is highly chemo-, diastereo-, and enantioselective for the preparation of a range of diamines, including those that have largely remained elusive until now.  The authors additionally highlight the differentiability of the products’ two amines thereby facilitating downstream synthesis

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