Research + Discoveries

  • Derbyshire Lab Targets Malaria Parasite in the Liver

    The Derbyshire Lab is attempting to target the Malaria-causing parasite, Plasmodium, in the liver before it can reach the red blood cells.  In their recent PLOS Pathogen publication, available here, Derbyshire lab members use an inhibitor to curtail the parasite’s ability to reproduce inside the liver.

    Read More
  • Derbyshire Lab Finds Hsp90 Inhibitors That May Aid in Treating Malaria

    The collaborative efforts of the Derbyshire and Haystead labs reveal that compounds that bind to Hsp90 represent a class of molecules that inhibit both blood- and liver-stage Plasmodium parasites. This dual-stage inhibition is ideal for antimalarials, and their work highlights the potential of Hsp90 inhibitors as drug partners in combination therapies.  Read more about this research in an April issue of Antimicrobial Agents and Chemotherapy article here.

    Read More
  • Franz Lab Demonstrates Copper’s Role in Antibacterial Mechanism of a Prochelator

    The Franz Lab and collaborators explored the antibacterial mechanism of PcephPT, a prodrug of the antimicrobial chelator pyrithione.  Graduate students Jacqueline Zaengle-Barone and Abigail Jackson and former grad student David Besse found that PcephPT has an unconventional mode of action, requiring β-lactamase expression and copper availability for maximal activity.

    Read More
  • Wang and Warren Collaboration Report a Novel Hyperpolarization Tagging Strategy

    A Departmental Collaboration is lighting up MRIs! Junu Bae of the Wang Lab and Zijian Zhou of the Warren Lab have developed chemical tags that attach to molecules, making them light up under MRI! Read more about these tags and how they could change how drugs target illness in the Wang/Warren lab article available in the March 9 publication of Science Advances.

    Read More
  • Charge Splitters and Charge Transport Junctions Based on Guanine Quadruplexes

    Professors David Beratan and Peng Zhang, with collaborators at NYU and ASU, have designed, built, and demonstrated current splitters and charge-transport junctions based on self-assembling nucleic acids. These constructs promise to expand the functionality of self-assembling bio-inspired electronic devices at the nanoscale.

    Read More