Research + Discoveries

  • Gold Carbene Complex Lacking Heteroatom Stabilization

    The Widenhoefer group has  recently reported the synthesis and structure of the first gold carbene complex lacking heteroatom stabilization.  Unstabilzied gold carbene complexes have been widely invoked as reactive intermediates in gold- catalyzed transformations but have heretofore escaped direct detection and characterization.  This work, co-authored with graduate student Robert Harris, recently appeared in Angewandte Chemie.

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  • Migliore and Collaborators re-ignite interest in DNA-based wires

    Dr Agostino Migliore and collaborators are taking a major step forward in understanding the basic rules of charge transport through long polymer  wires and in their implementation in more complex electrical circuits. Their work recently appeared in Nature Nanotechnology and is a result of an international collaboration led by the experimental group of Prof. Danny Porath (from The Hebrew University of Jerusalem) and involving experimentalists and theorists from Israel, USA, and Europe.

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  • Professor Derbyshire and Colleagues Find New Ways to Fight Malaria

    Professor Derbyshire is the lead author on a new study that identifies several kinase inhibitors that show promise as anti-malarial drugs.  The work, which was recently published online in ChemBioChem, was also highlighted in the August 25, 2014 article in Duke Today and in the October 2, 2014 article in Duke Today.

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  • Franz Group Develops a Strategy to Recruit Copper to Kill Pathogens

    Members of the Franz lab joined forces with collaborators in the Duke University Medical School to show that a small molecule enhances antifungal activity by taking advantage of chemical processes induced by the immune system.  The molecule, nicknamed QBP, transforms from a non-toxic compound to a lethal agent upon interacting with reactive oxygen species and copper, both of which are released by activated immune cells. The toxic agent overrides the copper detoxification machinery in microbial pathogens in a way that minimizes damage to uninfected host cells.

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  • Fitzgerald Group Advances Protein-Ligand Binding Methodology

    The Fitzgerald Group recently described the development and application of two new experimental protocols that significantly expand the scope of  their SPROX methodology for the large-scale and high-throughput analysis of protein-ligand binding interactions on the proteomic scale.

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