Research + Discoveries

  • Charbonneau's Glass-Forming Liquids Featured in La Recherche

    Charbonneau and collaborators have recently made the stunning prediction that, upon cooling, simple glass-forming liquids can form two different types of amorphous solids.  This work and the broader scientific context for this fundamental advance is featured this month in the French popular science magazine, La Recherche.  A link to the article, though in French, may be found here:

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  • Connecting long noncoding RNA structures and biochemical functions to disease

    The Hargrove lab discusses progress towards the molecular characterization of long noncoding RNAs (lncRNAs), a relatively new class of biomacromolecules implicated in a wide range of biological processes and human diseases. Despite the widely-recognized importance of lncRNAs, biochemical and biophysical studies are still in early stages.

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  • Derbyshire Lab Targets Malaria

    The Derbyshire Lab reports the discovery of inhibitors that target multiple stages of malaria  parasite growth.

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  • Bind One Get One Free

    Researchers in the Franz lab have built a peptide that binds one kind of metal ion with greater ease if it binds a different type of metal ion first. This unique example of cooperative, heterometallic allostery in a biologically compatible construct suggests the possibility of designing conditionally active metal-binding agents that could respond to dynamic changes in cellular metal status.

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  • Reviewing the Complex Worlds of Lysine Demethylation

    A new review from the McCafferty lab focuses on KDM1 class lysine demethylases. These enzymes are integrally involved in many biological processes and diseases and are therefore promising therapeutic targets. The comprehensive review describes the unique structure and substrate specificity of these enzymes, as well as current efforts toward inhibitor development. It further explores the regulation of KDM1 function through the formation of multiprotein complexes.

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