Research + Discoveries

  • Interdisciplinary Efforts Lead to Imaging Tag for MRI

    In a collaborative and highly interdisciplinary effort, the Wang, Warren, Malcolmson, Blum, and Theis labs have disclosed a new class of molecules that may be used as biomolecular tags for MRI, potentially enabling metabolic processes to be viewed in real time.  The work, published in the journal Science Advances and highlighted in Duke Today, details the hyperpolarization of these molecules through an iridium-catalyzed spin-polarization transfer from singlet-state hydrogen gas, increasing NMR signals,

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  • Charbonneau's Glass-Forming Liquids Featured in La Recherche

    Charbonneau and collaborators have recently made the stunning prediction that, upon cooling, simple glass-forming liquids can form two different types of amorphous solids.  This work and the broader scientific context for this fundamental advance is featured this month in the French popular science magazine, La Recherche.  A link to the article, though in French, may be found here:

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  • Connecting long noncoding RNA structures and biochemical functions to disease

    The Hargrove lab discusses progress towards the molecular characterization of long noncoding RNAs (lncRNAs), a relatively new class of biomacromolecules implicated in a wide range of biological processes and human diseases. Despite the widely-recognized importance of lncRNAs, biochemical and biophysical studies are still in early stages.

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  • Derbyshire Lab Targets Malaria

    The Derbyshire Lab reports the discovery of inhibitors that target multiple stages of malaria  parasite growth.

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  • Bind One Get One Free

    Researchers in the Franz lab have built a peptide that binds one kind of metal ion with greater ease if it binds a different type of metal ion first. This unique example of cooperative, heterometallic allostery in a biologically compatible construct suggests the possibility of designing conditionally active metal-binding agents that could respond to dynamic changes in cellular metal status.

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