Research

Research + Discoveries

  • Franz lab discovers relationship between copper levels and drug tolerance in fungal pathogen Candida albicans

    Lizzie Hunsaker of the Franz lab has discovered that modulating copper levels in the growth environment of Candida albicans reduces tolerance of this pathogen to widely prescribed azole antifungal drugs. Their results suggest that, even though these drugs are capable of coordinating transition metal centers, the observed copper-potentiated activity is not due to the formation of a copper complex. Instead, the data point to a broader relationship between Cu homeostasis and azole antifungals, a relationship that the lab continues to explore.

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  • Malcolmson Lab Develops Enantioselective Alkylations of Enolates with Dienes

    The Malcolmson lab has demonstrated that internal dienes may undergo regio- and enantioselective additions of enolate pronuclephiles. The transformations are promoted by Pd(PHOX) and Bronsted acid co-catalysts and deliver numerous products bearing 1,2-disubstituted olefins and a variety of alkyl groups at the stereogenic carbon. Read more about this research here in Chemical Science.

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  • Derbyshire Lab Discovers Chemical Probe that Reveals Malaria Parasite Signaling

    Rene Raphemot, Amber Eubanks, and other members of the Derbyshire lab, in collaboration with the Haystead lab in the Pharmacology department, have discovered the first reported inhibitors of an atypical Plasmodium kinase - PK9. Their results suggest that this protein kinase is important in ubiquitin signaling in the malaria parasite, and inhibition of this pathway leads to a unique growth of parasites during liver stage infection. These advancements lend insights into novel parasite biology.

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  • Beratan Lab Using Voltage to Induce Coherent Long-Range Electron Transport

    An international collaboration with the Beratan lab reports in Proceedings of the National Academy of Sciences that voltages may induce coherent long-range electron transport through biomolecules and other molecular structures. The authors describe a novel transport mechanism that supports electron flow across appreciable distances utilizing voltage-induced long-range electronic delocalization. This mechanism explains experiments that find a weak temperature dependence for long range electron transfer in biochemical and synthetic structures.

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  • Roizen Lab Opens Door to Engaging Sulfamate Esters in Site-Selective Functionalization of Small Molecules

    The Roizen laboratory is developing a strategy to employ the intrinsic geometric constraints of a molecule to alter of the site of C-H functionalization reactions. Previously, they had demonstrated that sulfamate esters could be used to guide site-selective chlorine-transfer to a typically unreactive C–H bond. This was the first demonstration that sulfamate esters could guide exogenous atom-transfer processes.  Their research, published in the Journal of Organic Chemistry, builds on this concept, suggesting that it may prove generally viable.

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