Research + Discoveries

  • Small Molecule Inhibitors Target a Key Enzyme in Lipid A Biosynthesis

    A team led by Professors Jiyong Hong and Pei Zhou has reported the molecular structure of LpxH in complex with a sulfonyl piperazine inhibitor and the identification of small molecule LpxH inhibitors with improved activity.

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  • Derbyshire Lab Illuminates the Early Stages of Plasmodium Liver Infection

    Recent work from the Derbyshire lab has led to a comprehensive view of the transcriptional dynamics of infection of liver cells by Plasmodium parasites, the causative agents of malaria.  Focusing on the parasite transcriptome, they identified clusters of genes functionally enriched for important liver-stage processes such as interactions with the host cell and redox homeostasis. Moreover, the group identified potential transcriptional factor - binding sites within these clusters, most which have never been characterized.

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  • Craig Group Opens Up Acid-generating Materials Response

    Ph.D. student Yangju Lin has reported in J. Am. Chem. Soc. a new mechanoacid that is used to report whether, where, and when potentially damaging mechanical events occur in bulk materials (read here!).

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  • Derbyshire Lab Investigating Coculture Growth Dynamics of Bacteria Isolated from Anopheles Mosquitoes

    The Derbyshire lab has recently published a communication in Chembiochem investigating coculture growth dynamics of bacteria isolated from Anopheles mosquitoes, the main vector for the transmission of malaria. Analysis of growth interactions between a dominant microbiome species, Elizabethkingia anophelis, and other mosquito-associated bacteria reveals that E. anophelis inhibits a Pseudomonas sp. through an antimicrobial-independent mechanism.

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  • Welsher Lab Speeds Up Live Cell Imaging

    Courtney Johnson of the Welsher lab has developed a new strategy for improving the speed of laser scanning microscopy. The technique, called 3D Fast Acquisition Scan by z-Translating Raster (3D-FASTR), uses an electrically tunable lens (ETL) to generate a reproducible 3D sparse sampling pattern which fully and efficiently scans a volume in the fastest possible time without repeating until the volume is complete. This method has shown a 4-fold improvement in the volumetric imaging rate of live cells.

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