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Derbyshire Lab Illuminates the Early Stages of Plasmodium Liver Infection

Recent work from the Derbyshire lab has led to a comprehensive view of the transcriptional dynamics of infection of liver cells by Plasmodium parasites, the causative agents of malaria.  Focusing on the parasite transcriptome, they identified clusters of genes functionally enriched for important liver-stage processes such as interactions with the host cell and redox homeostasis. Moreover, the group identified potential transcriptional factor - binding sites within these clusters, most which have never been characterized. Their work provides insights into the parasite transcriptional fluxes that may facilitate establishment of infection, transformation and replication in the liver. Read more about their exciting discoveries in mBio, available here.

Derbyshire