Research + Discoveries

Derbyshire Lab Discovers Chemical Probe that Reveals Malaria Parasite Signaling

Rene Raphemot, Amber Eubanks, and other members of the Derbyshire lab, in collaboration with the Haystead lab in the Pharmacology department, have discovered the first reported inhibitors of an atypical Plasmodium kinase - PK9. Their results suggest that this protein kinase is important in ubiquitin signaling in the malaria parasite, and inhibition of this pathway leads to a unique growth of parasites during liver stage infection. These advancements lend insights into novel parasite biology. Read more in Cell Chemical Biology, available here.