Hargrove Group


Current Work

Donlic, A.; Morgan, B.S.; Xu, J.L.; Liu, A.; Roble Jr., C.; and Hargrove, A.E. "Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold" Angew. Chem. Int. Ed. 2018, 40, 13242-13247. DOI: 10.1002/anie.201808823

Morgan, B.S.; Forte, J.E.; and Hargrove, A.E. "Insights into the Development of Chemical Probes for RNA" Nucleic Acids Res. 2018, 16,  8025-8037. DOI: 10.1093/nar/gky718

Donlic, A. and Hargrove, A.E. "Targeting RNA in Mammalian Systems with Small Molecules" WIREs RNA 2018,  9:(4e1477. DOI: 10.1002/wrna.1477
This article was featured in Advanced Science News

Eubanks, C.S. and Hargrove, A.E. "Sensing the Impact of Environment on Small Molecule Differentiation of RNA Sequences" Chem. Comm. 2017, 53, 13363-13366. DOI: 10.1039/C7CC07157D

This article is part of the themed collection: Chemosensors and Molecular Logic

Morgan, B.S.; Forte, J.E.; Culver, R.N.; Zhang, Y.; Hargrove, A.E. "Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-targeted Bioactive Ligands" Angew. Chem. Int. Ed. 2017, 56, 13498-13502. DOI: 10.1002/anie.201707641

This work was featured on Duke's Research Blog!

Patwardhan, N. N.; Ganser, L. R.; Kapral, G. J.; Eubanks, C. S.; Lee, J.; Sathyamoorthy, B.; Al-Hashimi, H. M.; Hargrove, A. E. "Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR."  MedChemComm. 2017, 8, 1022-1036. DOI: 10.1039/C6MD00729E
This article is part of the themed collection: 2017 Hot Articles in MedChemComm

Eubanks, C.S.; Forte, J.E.; Kapral, G. J.; Hargrove, A.E. "Small Molecule-Based Pattern Recognition to Classify RNA Structure." Journal of the American Chemical Society. 2017, 139, 409-416. DOI: 10.1021/jacs.6b11087.


This paper has been recommended as being of special significance by F1000 Prime. 

McFadden, E.J.; Hargrove, A.E. "Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin." Biochemistry2016, 55, 1615-1630. DOI: 10.1021/acs.biochem.5b01141.


Morgan, B.S.; Hargrove, A.E. "Chapter 7 Synthetic Receptors for Oligonucleotides and Nucleic Acids." In Synthetic Receptors for Biomolecules: Design Principles and Applications; Smith, B.D., Ed.; The Royal Society of Chemistry: Cambridge, 2015, p 253. DOI: 10.1039/9781782622062-00253


Burg, J.M.; Link, J.E.; Morgan, B.S.; Heller, F.J.; Hargrove, A.E.; McCafferty, D.G. "KDM1 Class Flavin-Dependent Protein Lysine Demethylases." Biopolymers. 2015104, 213-246.  DOI: 10.1002/bip.22643


Previous Work

Hargrove, A.E.; Martinez, T.F.; Hare, A.A.; Kurmis, A.A.; Philips, J.W.; Sud, S.; Pienta, K.J.; Dervan, P.B. "Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide."PLoS One, 2015, 10, 11.

Nickols, N. G.; Szablowski, J. O.; Hargrove, A. E.; Li, B. C.; Raskatov, J. A.; Dervan, P. B. "Activity of a Py-Im polyamide targeted to the estrogen response element." Molecular Cancer Therapeutics, 2013, 12, 675-684.

Jevgenij A. Raskatov, Nickolas G. Nickols, Amanda E. Hargrove, Georgi Marinov, Barbara Wold and Peter B. Dervan. “Gene Expression Changes in a Tumor Xenograft by a Py-Im Polyamide.” Proceedings of the National Academy of Sciences. 2012, 109, 16041-16045.

Hargrove, Amanda E.; Raskatov, Jevgenij A.; Meier, Jordan L.; Montgomery, David C.; Dervan, Peter B. “Characterization and solubilization of pyrrole-imidazole polyamide aggregates.” Journal of Medicinal Chemistry. 2012, 55, 5425-5432.

Raskatov, Jevgenij A.; Hargrove, Amanda E.; So, Alex Y.; Dervan, Peter B. “Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear.” Journal of the American Chemical Society. 2012, 134(18), 7995-7999.

Hargrove, Amanda E.; Nieto, Sonia; Zhang, Tianzhi; Sessler, Jonathan L.; Anslyn, Eric V. “Artificial receptors for the recognition of phosphorylated molecules.” Chemical Reviews. 2011, 111(11), 6603-6782.

Hargrove, Amanda E.; Ellington, Andrew D.; Anslyn, Eric V.; Sessler, Jonathan L. “Chemical functionalization of oligodeoxynucleotides with multiple boronic acids for the polyvalent binding of saccharides.” Bioconjugate Chemistry. 2011, 22, 388-396.

Hargrove, Amanda E.; Reyes, Ryan N.; Riddington, Ian; Anslyn, Eric V.; Sessler, Jonathan L. “Boronic acid porphyrin receptor for ginsenoside sensing.” Organic Letters. 2010, 12(21), 4804-4807.

Hargrove, Amanda E.; Zhong, Zhenlin; Shabbir, Shagufta H.; Sessler, Jonathan L., Anslyn, Eric V. “Algorithms for the determination of binding constants and enantiomeric excess in complex host:guest equilibria using optical measurements.” New Journal of Chemistry. 2010, 34, 348-354

Collins, Byron E.; Sorey, Steven; Hargrove, Amanda E.; Shabbir, Shagufta H.; Lynch, Vincent M.; Anslyn, Eric V.  “Probing intramolecular B-N interactions in protic media.” Journal of Organic Chemistry, 2009, 74(11), 4055 - 4066.

Pikulski, Michael; Hargrove, Amanda; Shabbir, Shagufta H.; Anslyn, Eric V.; Brodbelt, Jennifer S. “Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap.”  Journal of the American Society for Mass Spectrometry, 2007, 18, 2094-2106.

Spence, John D.; Hargrove, Amanda E.; Crampton, Hannah L.; Thomas, David W. “Porphyrenediynes: synthesis and cyclization of meso-enediynylporphyrins.” Tetrahedron Letters, 2007, 48(4), 725-728.

Sessler, Jonathan L.; Lee, Jeong Tae; Ou, Zhongping; Köhler, Thomas; Hargrove, Amanda E.; Cho, Won-Seob; Lynch, Vincent; Kadish, Karl M.  “Chemical and electrochemical oxidation of N-alkyl cyclo[n]pyrroles.” Journal of Porphyrins and Phthalocyanines, 2006, 10, 1329-1336.