Dr. Lizzie Hunsaker of the Franz lab has discovered that Candida albicans comprehensively remodels handling of transition metals in response to antifungal drug stress. Specifically, they find that treatment with the antifungal drug fluconazole increases the cell’s need for transition metals and regulation of metal homeostasis is crucial for C. albicans to meet these needs. The findings suggest that inducing vulnerabilities in metal handling pathways could be leveraged to optimize the efficacy of existing antimicrobial drugs as well as aid in the development of new drugs. Read more about this discovery here in Metallomics.
Chemistry
