Hargrove Group

Publications

Current Work

Morgan, B. S.;  Sanaba, B. G.;  Donlic, A.;  Karloff, D. B.;  Forte, J. E.;  Zhang, Y.; Hargrove, A. E. "R-BIND: An Interactive Database for Exploring and Developing RNA-Targeted Chemical Probes." ACS Chemical Biology, 2019, Article ASAP. DOI: 10.1021/acschembio.9b00631

rbind

Patwardhan, N. N.;  Cai, Z.;  Umuhire Juru, A.; Hargrove, A. E. "Driving factors in amiloride recognition of HIV RNA targets." Organic & Biomolecular Chemistry, 2019, Advance Article. DOI: 10.1039/C9OB01702J

dma2

Padroni, G.;  Eubanks, C. S.; Hargrove, A. E. "Differentiation and classification of RNA motifs using small molecule-based pattern recognition." Methods in Enzymology, 2019, 623, 101-130. DOI: 10.1016/bs.mie.2019.05.022

mie

Wicks, S. L.; Hargrove, A. E. "Fluorescent indicator displacement assays to identify and characterize small molecule interactions with RNA." Methods. 2019, 167, 3-14. DOI: 10.1016/j.ymeth.2019.04.018

Methods

Juru, A. U.; Patwardhan, N. N.; Hargrove, A. E. "Understanding the Contributions of Conformational Changes, Thermodynamics, and Kinetics of RNA–Small Molecule Interactions." ACS Chem. Biol. 2019, 14(5), 824-838. DOI: 10.1021/acschembio.8b00945

ACS

Eubanks, C. S.;  Zhao, B.;  Patwardhan, N. N.;  Thompson, R. D.;  Zhang, Q.; Hargrove, A. E. "Visualizing RNA conformational changes via Pattern Recognition of RNA by Small Molecules.” J. Am. Chem. Soc. 2019, 141 (14), 5692-5698. DOI: 10.1021/jacs.8b09665 

pattern rec sm

Eubanks, C. S.; Hargrove, A. E. "RNA Structural Differentiation: Opportunities with Pattern Recognition." Biochem. 2019, 58, 199-213DOI: 10.1021/acs.biochem.8b01090
prrsm

Part of the Future of Biochemistry: The International Issue special issue.

Patwardhan, N. P.; Cai, Z.; Newson, C. N.; Hargrove, A. E. "Fluorescent peptide displacement assay as a general assay for screening small molecule libraries against RNA." Org. Biomol. Chem. 2019, 17, 1778 - 1786. DOI: 10.1039/c8ob02467g
toc

This article is part of themed collections: New Talent and Chemical Biology in OBC.
This work was also highlighted in the Organic and Biomolecular Chemistry blog!

Donlic, A.; Morgan, B. S.; Xu, J. L.; Liu, A.; Roble Jr., C.; Hargrove, A. E. "Discovery of Small Molecule Ligands for MALAT1 by Tuning an RNA-Binding Scaffold." Angew. Chem. Int. Ed. 2018, 40, 13242-13247. DOI: 10.1002/anie.201808823
dpf
Chen, G. and Edwards, N: F1000Prime Recommendation of Evaluation [Donlic A et al., Angew Chem Int Ed Engl 2018 57(40):13242-13247]. In F1000Prime, 21 Nov 2018; 10.3410/f.733852452.793552881

Morgan, B. S.; Forte, J. E.; Hargrove, A.E. "Insights into the Development of Chemical Probes for RNA." Nucleic Acids Res. 2018, 16, 8025-8037. DOI: 10.1093/nar/gky718
nar
Chaires J: F1000Prime Recommendation of Evaluation [Morgan BS et al., Nucleic Acids Res 2018 46(16):8025-8037]. In F1000Prime, 04 Sep 2018; 10.3410/f.733808492.793550119

Donlic, A.; Hargrove, A. E. "Targeting RNA in Mammalian Systems with Small Molecules." WIREs RNA 2018,  9:(4e1477. DOI: 10.1002/wrna.1477
isksk
This article was featured in Advanced Science News

Eubanks, C. S.; Hargrove, A. E. "Sensing the Impact of Environment on Small Molecule Differentiation of RNA Sequences." Chem. Comm. 2017, 53, 13363-13366. DOI: 10.1039/C7CC07157D
fj

This article is part of the themed collection: Chemosensors and Molecular Logic

Morgan, B. S.; Forte, J. E.; Culver, R. N.; Zhang, Y.; Hargrove, A. E. "Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-targeted Bioactive Ligands." Angew. Chem. Int. Ed. 2017, 56, 13498-13502. DOI: 10.1002/anie.201707641
aja

This work was featured on Duke's Research Blog!

Patwardhan, N. N.; Ganser, L. R.; Kapral, G. J.; Eubanks, C. S.; Lee, J.; Sathyamoorthy, B.; Al-Hashimi, H. M.; Hargrove, A. E. "Amiloride as a new RNA-binding scaffold with activity against HIV-1 TAR."  Med. Chem. Comm. 2017, 8, 1022-1036. DOI: 10.1039/C6MD00729E
 akak
This article is part of the themed collection: 2017 Hot Articles in MedChemComm

Eubanks, C. S.; Forte, J. E.; Kapral, G. J.; Hargrove, A. E. "Small Molecule-Based Pattern Recognition to Classify RNA Structure." J. Am. Chem. Soc. 2017, 139, 409-416. DOI: 10.1021/jacs.6b11087.

soak

Arora P and Barros S: F1000Prime Recommendation of Evaluation [Eubanks CS et al., J Am Chem Soc 2017 139(1):409-416]. In F1000Prime, 07 Jun 2017; 10.3410/f.727137423.793532776
Bujnicki J and Almeida C: F1000Prime Recommendation of Evaluation [Eubanks CS et al., J Am Chem Soc 2017 139(1):409-416]. In F1000Prime, 21 Jun 2017; 10.3410/f.727137423.793533363

McFadden, E. J.; Hargrove, A. E. "Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin." Biochem2016, 55, 1615-1630. DOI: 10.1021/acs.biochem.5b01141.

oak

Morgan, B. S.; Hargrove, A. E., Chapter 7 Synthetic Receptors for Oligonucleotides and Nucleic Acids. In Synthetic Receptors for Biomolecules: Design Principles and Applications, The Royal Society of Chemistry: 2015; pp 253-325. DOI: 10.1039/9781782622062-00253

ajaj

Burg, J. M.; Link, J. E.; Morgan, B. S.; Heller, F. J.; Hargrove, A. E.; McCafferty, D. G. "KDM1 Class Flavin-Dependent Protein Lysine Demethylases." Biopolymers 2015104, 213-246.  DOI: 10.1002/bip.22643

Oo

Previous Work

Hargrove, A. E.; Martinez, T. F.; Hare, A. A.; Kurmis, A. A.; Philips, J. W.; Sud, S.; Pienta, K. J.; Dervan, P. B. "Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide."PLoS One, 2015, 10, 11.

Nickols, N. G.; Szablowski, J. O.; Hargrove, A. E.; Li, B. C.; Raskatov, J. A.; Dervan, P. B. "Activity of a Py-Im polyamide targeted to the estrogen response element." Mol. Cancer Ther. 2013, 12, 675-684.

Raskatov, J. A.; Nickols, N. G.; Hargrove, A. E.; Marinov, G.; Wold, B.; Dervan, P. B. “Gene Expression Changes in a Tumor Xenograft by a Py-Im Polyamide.” Proceedings of the National Academy of Sciences. 2012, 109, 16041-16045.

Hargrove, A. E.; Raskatov, J. A.; Meier, J. L.; Montgomery, D. C.; Dervan, P. B. “Characterization and solubilization of pyrrole-imidazole polyamide aggregates. J. Med. Chem. 2012, 55, 5425-5432.

Raskatov, J. A.; Hargrove, A. E.; So, A. Y.; Dervan, P. B. “Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear.” J. Am. Chem. Soc. 2012, 134(18), 7995-7999.

Hargrove, A. E.; Nieto, S.; Zhang, T.; Sessler, J. L.; Anslyn, E. V. “Artificial receptors for the recognition of phosphorylated molecules.” Chem. Rev. 2011, 111(11), 6603-6782.

Hargrove, A. E.; Ellington, A. D.; Anslyn, E. V.; Sessler, J. L. “Chemical functionalization of oligodeoxynucleotides with multiple boronic acids for the polyvalent binding of saccharides.” Bioconjugate Chem. 2011, 22, 388-396.

Hargrove, A. E.; Reyes, R. N.; Riddington, I.; Anslyn, E. V.; Sessler, J. L. “Boronic acid porphyrin receptor for ginsenoside sensing.” Org. Lett. 2010, 12(21), 4804-4807.

Hargrove, A. E.; Zhong, Z.; Shabbir, S. H.; Sessler, J. L., Anslyn, E. V. “Algorithms for the determination of binding constants and enantiomeric excess in complex host:guest equilibria using optical measurements.” New J. Chem. 2010, 34, 348-354

Collins, B. E.; Sorey, S.; Hargrove, A. E.; Shabbir, S. H.; Lynch, V. M.; Anslyn, E. V.  “Probing intramolecular B-N interactions in protic media.” J. Org. Chem. 2009, 74(11), 4055 - 4066.

Pikulski, M.; Hargrove, A. E.; Shabbir, S. H.; Anslyn, E. V.; Brodbelt, J. S. “Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap.”  J. Am. Soc. Mass Spectr. 2007, 18, 2094-2106.

Spence, J. D.; Hargrove, A. E.; Crampton, H. L.; Thomas, D. W. “Porphyrenediynes: synthesis and cyclization of meso-enediynylporphyrins.” Tetrahedron Lett. 2007, 48(4), 725-728.

Sessler, J. L.; Lee, J. T.; Ou, Z.; Köhler, T.; Hargrove, A. E.; Cho, W; Lynch, V; Kadish, K. M.  “Chemical and electrochemical oxidation of N-alkyl cyclo[n]pyrroles.” J. Porphyr. Phthalocya. 2006, 10, 1329-1336.

images: 
sjsj
aoak
apkp
akak
sdpk
apak
apajv
apoj
sjiasojd
DPF
ofdjdo
odfjo
prrsm
pattern rec sm
ACS Chem Bio
Methods Assay
kl
dma2
rbind
Image Slideshow: 
mie