Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Nobles, KN, Guan, Z, Xiao, K, Oas, TG, and Lefkowitz, RJ. "The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2." The Journal of Biological Chemistry 282.29 (July 2007): 21370-21381. Full Text

Whalen, EJ, Foster, MW, Matsumoto, A, Ozawa, K, Violin, JD, Que, LG, Nelson, CD, Benhar, M, Keys, JR, Rockman, HA, Koch, WJ, Daaka, Y, Lefkowitz, RJ, and Stamler, JS. "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2." CELL 129.3 (May 4, 2007): 511-522. Full Text

Whalen, EJ, Foster, MW, Matsumoto, A, Ozawa, K, Violin, JD, Que, LG, Nelson, CD, Benhar, M, Keys, JR, Rockman, HA, Koch, WJ, Daaka, Y, Lefkowitz, RJ, and Stamler, JS. "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2." Cell 129.3 (May 4, 2007): 511-522. Full Text

Lefkowitz, RJ. "Seven transmembrane receptors: something old, something new." Acta Physiologica (Oxford, England) 190.1 (May 2007): 9-19. (Review) Full Text

Girnita, L, Shenoy, SK, Sehat, B, Vasilcanu, R, Vasilcanu, D, Girnita, A, Lefkowitz, RJ, and Larsson, O. "Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression." The Journal of Biological Chemistry 282.15 (April 2007): 11329-11338. Full Text

Lefkowitz, RJ. "Seven transmembrane receptors: a brief personal retrospective." Biochimica Et Biophysica Acta 1768.4 (April 2007): 748-755. Full Text

DeWire, SM, Ahn, S, Lefkowitz, RJ, and Shenoy, SK. "β-Arrestins and Cell Signaling." Annual Review of Physiology 69.1 (March 2007): 483-510. Full Text

Nelson, CD, Perry, SJ, Regier, DS, Prescott, SM, Topham, MK, and Lefkowitz, RJ. "Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins." Science (New York, N.Y.) 315.5812 (February 2007): 663-666. Full Text

DeWire, SM, Ahn, S, Lefkowitz, RJ, and Shenoy, SK. "Beta-arrestins and cell signaling." Annual Review of Physiology 69 (January 2007): 483-510. (Review) Full Text

Lefkowitz, R. "Introduction to special section on β-arrestins." Annual Review of Physiology 69 (2007): xi-xii.

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