Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Drake, MT, Violin, JD, Whalen, EJ, Wisler, JW, Shenoy, SK, and Lefkowitz, RJ. "beta-arrestin-biased agonism at the beta2-adrenergic receptor." The Journal of Biological Chemistry 283.9 (February 2008): 5669-5676. Full Text

Violin, JD, DiPilato, LM, Yildirim, N, Elston, TC, Zhang, J, and Lefkowitz, RJ. "beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics." The Journal of Biological Chemistry 283.5 (February 2008): 2949-2961. Full Text

Lefkowitz, RJ, Sun, J-P, and Shukla, AK. "A crystal clear view of the beta2-adrenergic receptor." Nat Biotechnol 26.2 (February 2008): 189-191. Full Text

Beaulieu, J-M, Marion, S, Rodriguiz, RM, Medvedev, IO, Sotnikova, TD, Ghisi, V, Wetsel, WC, Lefkowitz, RJ, Gainetdinov, RR, and Caron, MG. "A beta-arrestin 2 signaling complex mediates lithium action on Behavior." CELL 132.1 (January 11, 2008): 125-136. Full Text

Beaulieu, J-M, Marion, S, Rodriguiz, RM, Medvedev, IO, Sotnikova, TD, Ghisi, V, Wetsel, WC, Lefkowitz, RJ, Gainetdinov, RR, and Caron, MG. "A beta-arrestin 2 signaling complex mediates lithium action on behavior." Cell 132.1 (January 2008): 125-136. Full Text

Wisler, JW, DeWire, SM, Whalen, EJ, Violin, JD, Drake, MT, Ahn, S, Shenoy, SK, and Lefkowitz, RJ. "A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling." Proceedings of the National Academy of Sciences of the United States of America 104.42 (October 9, 2007): 16657-16662. Full Text

Shenoy, SK, Barak, LS, Xiao, K, Ahn, S, Berthouze, M, Shukla, AK, Luttrell, LM, and Lefkowitz, RJ. "Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation." The Journal of Biological Chemistry 282.40 (October 2007): 29549-29562. Full Text

Noma, T, Lemaire, A, Naga Prasad, SV, Barki-Harrington, L, Tilley, DG, Chen, J, Le Corvoisier, P, Violin, JD, Wei, H, Lefkowitz, RJ, and Rockman, HA. "Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection." The Journal of Clinical Investigation 117.9 (September 2007): 2445-2458. Full Text Open Access Copy

Violin, JD, and Lefkowitz, RJ. "Beta-arrestin-biased ligands at seven-transmembrane receptors." Trends in Pharmacological Sciences 28.8 (August 2007): 416-422. (Review) Full Text

Xiao, K, McClatchy, DB, Shukla, AK, Zhao, Y, Chen, M, Shenoy, SK, Yates, JR, and Lefkowitz, RJ. "Functional specialization of beta-arrestin interactions revealed by proteomic analysis." Proceedings of the National Academy of Sciences of the United States of America 104.29 (July 9, 2007): 12011-12016. Full Text

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