Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Barak, LS, Salahpour, A, Zhang, X, Masri, B, Sotnikova, TD, Ramsey, AJ, Violin, JD, Lefkowitz, RJ, Caron, MG, and Gainetdinov, RR. "Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor." Molecular Pharmacology 74.3 (September 2008): 585-594. Full Text

Ozawa, K, Whalen, EJ, Nelson, CD, Mu, Y, Hess, DT, Lefkowitz, RJ, and Stamler, JS. "S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking." Molecular Cell 31.3 (August 2008): 395-405. Full Text

Shukla, AK, Violin, JD, Whalen, EJ, Gesty-Palmer, D, Shenoy, SK, and Lefkowitz, RJ. "Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors." Proceedings of the National Academy of Sciences of the United States of America 105.29 (July 11, 2008): 9988-9993. Full Text

Kim, J, Zhang, L, Peppel, K, Wu, J-H, Zidar, DA, Brian, L, DeWire, SM, Exum, ST, Lefkowitz, RJ, and Freedman, NJ. "Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration." Circulation Research 103.1 (July 2008): 70-79. Full Text Open Access Copy

Nelson, CD, Kovacs, JJ, Nobles, KN, Whalen, EJ, and Lefkowitz, RJ. "Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor." The Journal of Biological Chemistry 283.30 (July 2008): 21093-21101. Full Text

Kovacs, JJ, Whalen, EJ, Liu, R, Xiao, K, Kim, J, Chen, M, Wang, J, Chen, W, and Lefkowitz, RJ. "Beta-arrestin-mediated localization of smoothened to the primary cilium." Science (New York, N.Y.) 320.5884 (June 2008): 1777-1781. Full Text

Shukla, AK, Sun, J-P, and Lefkowitz, RJ. "Crystallizing thinking about the beta2-adrenergic receptor." Mol Pharmacol 73.5 (May 2008): 1333-1338. Full Text

DeWire, SM, Kim, J, Whalen, EJ, Ahn, S, Chen, M, and Lefkowitz, RJ. "Beta-arrestin-mediated signaling regulates protein synthesis." The Journal of Biological Chemistry 283.16 (April 2008): 10611-10620. Full Text

Lefkowitz, RJ. "The annual ASCI meeting: does nostalgia have a future?." The Journal of Clinical Investigation 118.4 (April 2008): 1231-1233. Full Text Open Access Copy

Violin, JD, DiPilato, LM, Yildirim, N, Elston, TC, Zhang, J, and Lefkowitz, RJ. "beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics." The Journal of Biological Chemistry 283.5 (February 2008): 2949-2961. Full Text

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