Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Xie, L, Xiao, K, Whalen, EJ, Forrester, MT, Freeman, RS, Fong, G, Gygi, SP, Lefkowitz, RJ, and Stamler, JS. "Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL." Science Signaling 2.78 (July 7, 2009): ra33-null. Full Text

Zidar, DA, Violin, JD, Whalen, EJ, and Lefkowitz, RJ. "Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands." Proc Natl Acad Sci U S A 106.24 (June 16, 2009): 9649-9654. Full Text

Walters, RW, Shukla, AK, Kovacs, JJ, Violin, JD, DeWire, SM, Lam, CM, Chen, JR, Muehlbauer, MJ, Whalen, EJ, and Lefkowitz, RJ. "beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice." The Journal of Clinical Investigation 119.5 (May 2009): 1312-1321. Full Text Open Access Copy

Shenoy, SK, Modi, AS, Shukla, AK, Xiao, K, Berthouze, M, Ahn, S, Wilkinson, KD, Miller, WE, and Lefkowitz, RJ. "Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2." Proc Natl Acad Sci U S A 106.16 (April 21, 2009): 6650-6655. Full Text

Walters, RW, Shukla, AK, Kovacs, JJ, Violin, JD, DeWire, SM, Lam, CM, Chen, JR, Muehlbauer, MJ, Whalen, EJ, and Lefkowitz, RJ. "Beta-arrestin1 mediates nicotinic acid induced flushing, but not its antilipolytic effect." JOURNAL OF INVESTIGATIVE DERMATOLOGY 129 (April 2009): S1-S1.

Shukla, AK, Kim, J, Ahn, S, Xiao, K, Liedtke, W, and Lefkowitz, RJ. "[beta]-arrestin 1 mediates angiotensin II induced ubiquitination and down-regulation of TRPV4." FASEB JOURNAL 23 (April 2009).

Ahn, S, Kim, J, Hara, MR, Ren, X-R, and Lefkowitz, RJ. "{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation." The Journal of Biological Chemistry 284.13 (March 2009): 8855-8865. Full Text

Tarrant, TK, Rampersad, RR, Esserman, D, Rothlein, LR, Liu, P, Premont, RT, Lefkowitz, RJ, Lee, DM, and Patel, DD. "Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)." Clinical Immunology (Orlando, Fla.) 129.1 (October 2008): 115-122. Full Text

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