Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
467 Clin & Res Labs, Durham, NC 27710
(919) 684-2974
(919) 684-8875



Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Whalen, EJ, Rajagopal, S, and Lefkowitz, RJ. "Therapeutic potential of β-arrestin- and G protein-biased agonists." Trends in Molecular Medicine 17.3 (March 2011): 126-139. (Review) Full Text

Lovgren, AK, Kovacs, JJ, Xie, T, Potts, EN, Li, Y, Foster, WM, Liang, J, Meltzer, EB, Jiang, D, Lefkowitz, RJ, and Noble, PW. "β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix." Science Translational Medicine 3.74 (March 2011): 74ra23-null. Full Text

Kenakin, T, Agnati, LF, Caron, M, Fredholm, B, Guidoli, D, Kobilka, B, Lefkowitz, RW, Lohse, M, Woods, A, and Fuxe, K. "International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?." Journal of Receptor and Signal Transduction Research 30.5 (October 2010): 284-286. Full Text

Shukla, AK, Kim, J, Ahn, S, Xiao, K, Shenoy, SK, Liedtke, W, and Lefkowitz, RJ. "Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4." The Journal of Biological Chemistry 285.39 (September 2010): 30115-30125. Full Text

Xiao, K, Sun, J, Kim, J, Rajagopal, S, Zhai, B, Villén, J, Haas, W, Kovacs, JJ, Shukla, AK, Hara, MR, Hernandez, M, Lachmann, A, Zhao, S, Lin, Y, Cheng, Y, Mizuno, K, Ma'ayan, A, Gygi, SP, and Lefkowitz, RJ. "Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)." Proceedings of the National Academy of Sciences of the United States of America 107.34 (August 4, 2010): 15299-15304. Full Text

Rajagopal, S, Rajagopal, K, and Lefkowitz, RJ. "Teaching old receptors new tricks: biasing seven-transmembrane receptors." Nature Reviews. Drug Discovery 9.5 (May 2010): 373-386. (Review) Full Text

Rajagopal, S, Kim, J, Ahn, S, Craig, S, Lam, CM, Gerard, NP, Gerard, C, and Lefkowitz, RJ. "Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7." Proceedings of the National Academy of Sciences of the United States of America 107.2 (January 2010): 628-632. Full Text

Chen, M, Philipp, M, Wang, J, Premont, RT, Garrison, TR, Caron, MG, Lefkowitz, RJ, and Chen, W. "G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway." The Journal of Biological Chemistry 284.50 (December 2009): 35040-35048. Full Text

Gesty-Palmer, D, Nabel, B, Lefkowitz, RJ, and Kelner, KL. "Science Translational Medicine Podcast: 7 October 2009." Science Translational Medicine 1.1 (October 7, 2009): 1pc1-1pc1. Full Text

Gesty-Palmer, D, Flannery, P, Yuan, L, Corsino, L, Spurney, R, Lefkowitz, RJ, and Luttrell, LM. "A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation." Science Translational Medicine 1.1 (October 2009): 1ra1-null. Full Text