Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Hara, MR, Sachs, BD, Caron, MG, and Lefkowitz, RJ. "Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model." Cell Cycle (Georgetown, Tex.) 12.2 (January 2013): 219-224. Full Text

Shukla, AK, Manglik, A, Kruse, AC, Xiao, K, Reis, RI, Tseng, W-C, Staus, DP, Hilger, D, Uysal, S, Huang, L-Y, Paduch, M, Tripathi-Shukla, P, Koide, A, Koide, S, Weis, WI, Kossiakoff, AA, Kobilka, BK, and Lefkowitz, RJ. "Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide." Nature 497.7447 (2013): 137-141. Full Text

Lefkowitz, RJ. "Arrestins come of age: a personal historical perspective." Progress in Molecular Biology and Translational Science 118 (January 2013): 3-18. (Review) Full Text

Fereshteh, M, Ito, T, Kovacs, JJ, Zhao, C, Kwon, HY, Tornini, V, Konuma, T, Chen, M, Lefkowitz, RJ, and Reya, T. "β-Arrestin2 mediates the initiation and progression of myeloid leukemia." Proceedings of the National Academy of Sciences of the United States of America 109.31 (July 5, 2012): 12532-12537. Full Text

Heitzler, D, Durand, G, Gallay, N, Rizk, A, Ahn, S, Kim, J, Violin, JD, Dupuy, L, Gauthier, C, Piketty, V, Crépieux, P, Poupon, A, Clément, F, Fages, F, Lefkowitz, RJ, and Reiter, E. "Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling." Molecular Systems Biology 8 (June 26, 2012): 590-null. Full Text

Reiter, E, Ahn, S, Shukla, AK, and Lefkowitz, RJ. "Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors." Annual Review of Pharmacology and Toxicology 52 (January 2012): 179-197. (Review) Full Text

Lefkowitz, RJ, and VanHook, AM. "Science Signaling Podcast: 20 November 2012." Science Signaling 5.251 (2012). Full Text

Xiao, K, Sun, J, Kim, J, Rajagopal, S, Zhai, B, Villén, J, Haas, W, Kovacs, JJ, Shukla, AK, Hara, MR, Hernandez, M, Lachmann, A, Zhao, S, Lin, Y, Cheng, Y, Mizuno, K, Ma'ayan, A, Gygi, SP, and Lefkowitz, RJ. "Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107)." Proceedings of the National Academy of Sciences of the United States of America 109.33 (2012): 13464--. Full Text

Lefkowitz, RJ. "An interview with Robert J. Lefkowitz." Trends in pharmacological sciences 33.2 (2012): 51-52.

Lefkowitz, R, and Kobilka, B. "A signal honour." Chemistry World 9.11 (2012): 46-49.

Pages

LOMASNEY, JW, COTECCHIA, S, LORENZ, W, SCHWINN, DA, CARON, MG, and LEFKOWITZ, RJ. "STRUCTURE AND MOLECULAR CHARACTERIZATION OF ALPHA-ADRENERGIC RECEPTORS." 1991.

Pages