Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Barnes, WG, Reiter, E, Violin, JD, Ren, X-R, Milligan, G, and Lefkowitz, RJ. "beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation." J Biol Chem 280.9 (March 4, 2005): 8041-8050. Full Text

Tachibana, H, Naga Prasad, SV, Lefkowitz, RJ, Koch, WJ, and Rockman, HA. "Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure." Circulation 111.5 (February 8, 2005): 591-597. Full Text Open Access Copy

Ren, X-R, Reiter, E, Ahn, S, Kim, J, Chen, W, and Lefkowitz, RJ. "Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor." Proceedings of the National Academy of Sciences of the United States of America 102.5 (February 2005): 1448-1453. Full Text

Kim, J, Ahn, S, Ren, X-R, Whalen, EJ, Reiter, E, Wei, H, and Lefkowitz, RJ. "Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling." Proceedings of the National Academy of Sciences of the United States of America 102.5 (February 2005): 1442-1447. Full Text

Shenoy, SK, and Lefkowitz, RJ. "Resonating to the music of ubiquitination." Nat Methods 1.3 (December 2004): 191-193. Full Text

Ge, L, Shenoy, SK, Lefkowitz, RJ, and DeFea, K. "Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2." The Journal of Biological Chemistry 279.53 (December 2004): 55419-55424. Full Text

Xiao, K, Shenoy, SK, Nobles, K, and Lefkowitz, RJ. "Activation-dependent conformational changes in {beta}-arrestin 2." The Journal of Biological Chemistry 279.53 (December 2004): 55744-55753. Full Text

Chen, W, Ren, X-R, Nelson, CD, Barak, LS, Chen, JK, Beachy, PA, de Sauvage, F, and Lefkowitz, RJ. "Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2." Science (New York, N.Y.) 306.5705 (December 2004): 2257-2260. Full Text

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