Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
467 Clin & Res Labs, Durham, NC 27710
(919) 684-2974
(919) 684-8875



Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Lefkowitz, RJ, Rajagopal, K, and Whalen, EJ. "New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors." Molecular Cell 24.5 (December 2006): 643-652. (Review) Full Text

Violin, JD, Dewire, SM, Barnes, WG, and Lefkowitz, RJ. "G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics." J Biol Chem 281.47 (November 24, 2006): 36411-36419. Full Text

Rajagopal, K, Whalen, EJ, Violin, JD, Stiber, JA, Rosenberg, PB, Premont, RT, Coffman, TM, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes." Proceedings of the National Academy of Sciences of the United States of America 103.44 (October 23, 2006): 16284-16289. Full Text

Meloni, AR, Fralish, GB, Kelly, P, Salahpour, A, Chen, JK, Wechsler-Reya, RJ, Lefkowitz, RJ, and Caron, MG. "Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2." Molecular and Cellular Biology 26.20 (October 2006): 7550-7560. Full Text Open Access Copy

Drake, MT, Shenoy, SK, and Lefkowitz, RJ. "Trafficking of G protein-coupled receptors." Circulation Research 99.6 (September 2006): 570-582. Full Text Open Access Copy

Reiter, E, and Lefkowitz, RJ. "GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling." Trends in Endocrinology and Metabolism: Tem 17.4 (May 2006): 159-165. (Review) Full Text

Gesty-Palmer, D, Chen, M, Reiter, E, Ahn, S, Nelson, CD, Wang, S, Eckhardt, AE, Cowan, CL, Spurney, RF, Luttrell, LM, and Lefkowitz, RJ. "Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation." The Journal of Biological Chemistry 281.16 (April 2006): 10856-10864. Full Text

Shenoy, SK, Drake, MT, Nelson, CD, Houtz, DA, Xiao, K, Madabushi, S, Reiter, E, Premont, RT, Lichtarge, O, and Lefkowitz, RJ. "beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor." The Journal of Biological Chemistry 281.2 (January 2006): 1261-1273. Full Text

Shenoy, SK, and Lefkowitz, RJ. "Receptor regulation: β-arrestin moves up a notch." Nature Cell Biology 7.12 (December 2005): 1159-1161. Full Text