Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Stoppel, LJ, Auerbach, BD, Senter, RK, Preza, AR, Lefkowitz, RJ, and Bear, MF. "β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X." Cell reports 18.12 (March 2017): 2807-2814. Full Text

Ahn, S, Kahsai, AW, Pani, B, Wang, Q-T, Zhao, S, Wall, AL, Strachan, RT, Staus, DP, Wingler, LM, Sun, LD, Sinnaeve, J, Choi, M, Cho, T, Xu, TT, Hansen, GM, Burnett, MB, Lamerdin, JE, Bassoni, DL, Gavino, BJ, Husemoen, G, Olsen, EK, Franch, T, Costanzi, S, Chen, X, and Lefkowitz, RJ. "Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library." Proceedings of the National Academy of Sciences of the United States of America 114.7 (February 2017): 1708-1713. Full Text

Kahsai, AW, Wisler, JW, Lee, J, Ahn, S, Cahill Iii, TJ, Dennison, SM, Staus, DP, Thomsen, ARB, Anasti, KM, Pani, B, Wingler, LM, Desai, H, Bompiani, KM, Strachan, RT, Qin, X, Alam, SM, Sullenger, BA, and Lefkowitz, RJ. "Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor." Nature Chemical Biology 12.9 (September 2016): 709-716. Full Text

Thomsen, ARB, Plouffe, B, Cahill, TJ, Shukla, AK, Tarrasch, JT, Dosey, AM, Kahsai, AW, Strachan, RT, Pani, B, Mahoney, JP, Huang, L, Breton, B, Heydenreich, FM, Sunahara, RK, Skiniotis, G, Bouvier, M, and Lefkowitz, RJ. "GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling." Cell 166.4 (August 4, 2016): 907-919. Full Text

Staus, DP, Strachan, RT, Manglik, A, Pani, B, Kahsai, AW, Kim, TH, Wingler, LM, Ahn, S, Chatterjee, A, Masoudi, A, Kruse, AC, Pardon, E, Steyaert, J, Weis, WI, Prosser, RS, Kobilka, BK, Costa, T, and Lefkowitz, RJ. "Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation." Nature 535.7612 (July 13, 2016): 448-452. Full Text

Lefkowitz, RJ. "Alfred Goodman Gilman (1941-2015)." Nature 529.7586 (January 2016): 284-null. Full Text

Wisler, JW, Harris, EM, Raisch, M, Mao, L, Kim, J, Rockman, HA, and Lefkowitz, RJ. "The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome." American Journal of Physiology. Heart and Circulatory Physiology 309.9 (November 2015): H1516-H1527. Full Text

Lefkowitz, RJ. "Inspiring the next generation of physician-scientists." The Journal of Clinical Investigation 125.8 (August 3, 2015): 2905-2907. Full Text

Soto, AG, Smith, TH, Chen, B, Bhattacharya, S, Cordova, IC, Kenakin, T, Vaidehi, N, and Trejo, J. "N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias." Proceedings of the National Academy of Sciences of the United States of America 112.27 (July 2015): E3600-E3608. Full Text

Tang, W, Strachan, RT, Lefkowitz, RJ, and Rockman, HA. "Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch." The Journal of Biological Chemistry 289.41 (October 2014): 28271-28283. Full Text

Pages

Shenoy, SK, Drake, MT, Nelson, CD, Houtz, DA, Xiao, KH, Madabushi, S, Reiter, E, Premont, RT, Lichtarge, O, and Lefkowitz, RJ. "beta-arrestin-dependent, G-protein-independent ERK1/2 activation by the beta(2)-adrenergic receptor." October 25, 2005.

Rajagopal, K, Whalen, EJ, Violin, JD, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin 2-dependent positive inotropic and lusitropic responses to angiotensin II receptor stimulation in cardiomyocytes." October 25, 2005.

Shenoy, SK, Drake, MT, Nelson, CD, Houtz, DA, Xiao, KH, Madabushi, S, Reiter, E, Premont, RT, Lichtarge, O, and Lefkowitz, RJ. "beta-arrestin dependent, G protein independent ERIK1/2 activation by the beta 2 adrenergic receptor." October 25, 2005.

Gesty-Palmer, D, Reiter, E, Spurney, RF, Luttrell, LM, and Lefkowitz, RJ. "Distinct conformations of the parathyroid hormone receptor mediate G protein and beta-arrestin dependent activation of ERK1/2." September 2005.

Xiao, KH, Shenoy, SK, Nobles, K, Oas, TG, and Lefkowitz, RJ. "Activation dependent conformational changes in beta-arrestin 2." January 2005.

Chakir, K, Zhang, SJ, Rhee, MH, Blumer, K, Lefkowitz, RJ, and Xiao, RP. "Use-dependent beta 2-adrenergic receptor-GI coupling requires RGS and beta-ARK/PKA-mediated receptor phosphorylation." October 26, 2004.

Walker, JKL, Lawson, BL, Schwartz, DA, and Lefkowitz, RJ. "beta-arrestin-2 regulation of lung eosinophilia in a mouse model of Th2-type airway inflammation." March 23, 2004.

Walker, JKL, Lawson, BL, Savov, JD, Schwartz, DA, and Lefkowitz, RJ. "[beta]-arrestin-2 regulates the development of allergic asthma in mice." March 17, 2003.

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