Faculty Profiles

Robert J. Lefkowitz
Professor of Chemistry
Office: 
467 Clin & Res Labs, Durham, NC 27710
Phone: 
(919) 684-2974
Fax: 
(919) 684-8875

Overview

Education:

Resident, Medicine, Massachusetts General Hospital 1970 - 1971

Resident, Medicine, Columbia University 1967 - 1968

Intern, Medicine, Columbia University 1966 - 1967

M.D., Columbia University 1966

Kim, Jihee, et al. “The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.Proc Natl Acad Sci U S A, vol. 117, no. 22, June 2020, pp. 12435–43. Pubmed, doi:10.1073/pnas.1920310117. Full Text

Manglik, Aashish, et al. “β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19.Circulation, May 2020. Pubmed, doi:10.1161/CIRCULATIONAHA.120.048723. Full Text

Staus, Dean P., et al. “Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.Nature, vol. 579, no. 7798, Mar. 2020, pp. 297–302. Pubmed, doi:10.1038/s41586-020-1954-0. Full Text

Suomivuori, Carl-Mikael, et al. “Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor.Science, vol. 367, no. 6480, Feb. 2020, pp. 881–87. Pubmed, doi:10.1126/science.aaz0326. Full Text

Nguyen, Anthony H., et al. “Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.Nat Struct Mol Biol, vol. 26, no. 12, Dec. 2019, pp. 1123–31. Pubmed, doi:10.1038/s41594-019-0330-y. Full Text

Staus, Dean P., et al. “Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein-coupled receptors.J Biol Chem, vol. 294, no. 36, Sept. 2019, pp. 13218–23. Pubmed, doi:10.1074/jbc.AC119.009848. Full Text

Jain, Mukesh K., et al. “Saving the Endangered Physician-Scientist - A Plan for Accelerating Medical Breakthroughs.N Engl J Med, vol. 381, no. 5, Aug. 2019, pp. 399–402. Pubmed, doi:10.1056/NEJMp1904482. Full Text

Liu, Xiangyu, et al. “Mechanism of β2AR regulation by an intracellular positive allosteric modulator.Science, vol. 364, no. 6447, June 2019, pp. 1283–87. Pubmed, doi:10.1126/science.aaw8981. Full Text

Wingler, Laura M., et al. “Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody.Cell, vol. 176, no. 3, Jan. 2019, pp. 479-490.e12. Pubmed, doi:10.1016/j.cell.2018.12.006. Full Text

Wingler, Laura M., et al. “Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.Cell, vol. 176, no. 3, Jan. 2019, pp. 468-478.e11. Pubmed, doi:10.1016/j.cell.2018.12.005. Full Text

Pages

Bond, R. A., and R. J. Lefkowitz. Historical Background and Introduction. Vol. 24, 2006, pp. 1–10. Scopus, doi:10.1002/352760734X.ch1. Full Text

Lefkowitz, R. J., et al. Biochemical mechanisms for regulation of β adrenergic receptors by β adrenergic agonists. Vol. No. 402, 1977, pp. 502–06.

Suomivuori, Carl-Mikael, et al. “Molecular Mechanism of Biased Signaling in a Prototypical G-proteincoupled Receptor.” Biophysical Journal, vol. 118, no. 3, CELL PRESS, 2020, pp. 162A-162A.

Cahill, T. J., et al. “LB987 New insights into gpcr-transducer coupling.” Journal of Investigative Dermatology, vol. 137, no. 10, Elsevier BV, 2017, pp. B10–B10. Crossref, doi:10.1016/j.jid.2017.07.067. Full Text

Lefkowitz, R. J. “Seven transmembrane receptors.” European Biophysics Journal With Biophysics Letters, vol. 46, SPRINGER, 2017, pp. S45–S45.

Smith, J. S., et al. “678 Biased CXCR3 ligands differentially alter allergic contact hypersensitivity and chemotaxis.” Journal of Investigative Dermatology, vol. 137, no. 5, Elsevier BV, 2017, pp. S117–S117. Crossref, doi:10.1016/j.jid.2017.02.701. Full Text

Rein, Lindsay A. M., et al. “beta-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis.” Blood, vol. 126, no. 23, AMER SOC HEMATOLOGY, 2015.

Rein, Lindsay A. M., et al. “Targeting β-arrestin2 Enhances Survival in a Murine Model of Chronic Myeloid Leukemia.” Blood, vol. 122, no. 21, American Society of Hematology, 2013, pp. 857–857. Crossref, doi:10.1182/blood.v122.21.857.857. Full Text

Weiss, Dahlia R., et al. “G-protein coupled receptors in virtual screening: Functional fidelity and selectivity.” Abstracts of Papers of the American Chemical Society, vol. 245, AMER CHEMICAL SOC, 2013.

Shukla, Arun K., et al. “Crystal structure of active Beta-arrestin1 bound to phosphorylated carboxy-terminus of a G protein-coupled receptor.” Faseb Journal, vol. 27, FEDERATION AMER SOC EXP BIOL, 2013.

Patel, Chetan B., et al. “A Modified beta 1-adrenergic Receptor Demonstrates Bias Towards G Protein Receptor Kinase Phosphorylation.” Circulation, vol. 120, no. 18, LIPPINCOTT WILLIAMS & WILKINS, 2009, pp. S800–01.

Pages

Willerson, J. T. “Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.Circulation, vol. 92, no. 3, 1 Aug. 1995, p. 277. Pubmed, doi:10.1161/01.cir.92.3.277. Full Text