
Resident, Medicine, Massachusetts General Hospital 1970 - 1971
Resident, Medicine, Columbia University 1967 - 1968
Intern, Medicine, Columbia University 1966 - 1967
M.D., Columbia University 1966
Pakharukova, Natalia, et al. “Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes.” J Biol Chem, vol. 295, no. 49, Dec. 2020, pp. 16773–84. Pubmed, doi:10.1074/jbc.RA120.015400. Full Text
Ahn, Seungkirl, et al. “SnapShot: β-Arrestin Functions.” Cell, vol. 182, no. 5, Sept. 2020, pp. 1362-1362.e1. Pubmed, doi:10.1016/j.cell.2020.07.034. Full Text
Wingler, Laura M., and Robert J. Lefkowitz. “Conformational Basis of G Protein-Coupled Receptor Signaling Versatility.” Trends Cell Biol, vol. 30, no. 9, Sept. 2020, pp. 736–47. Pubmed, doi:10.1016/j.tcb.2020.06.002. Full Text
McMahon, Conor, et al. “Synthetic nanobodies as angiotensin receptor blockers.” Proc Natl Acad Sci U S A, vol. 117, no. 33, Aug. 2020, pp. 20284–91. Pubmed, doi:10.1073/pnas.2009029117. Full Text
Manglik, Aashish, et al. “β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19.” Circulation, vol. 142, no. 4, July 2020, pp. 318–20. Pubmed, doi:10.1161/CIRCULATIONAHA.120.048723. Full Text
Kim, Jihee, et al. “The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility.” Proc Natl Acad Sci U S A, vol. 117, no. 22, June 2020, pp. 12435–43. Pubmed, doi:10.1073/pnas.1920310117. Full Text
Staus, Dean P., et al. “Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.” Nature, vol. 579, no. 7798, Mar. 2020, pp. 297–302. Pubmed, doi:10.1038/s41586-020-1954-0. Full Text
Suomivuori, Carl-Mikael, et al. “Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor.” Science, vol. 367, no. 6480, Feb. 2020, pp. 881–87. Pubmed, doi:10.1126/science.aaz0326. Full Text
Nguyen, Anthony H., et al. “Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex.” Nat Struct Mol Biol, vol. 26, no. 12, Dec. 2019, pp. 1123–31. Pubmed, doi:10.1038/s41594-019-0330-y. Full Text
Staus, Dean P., et al. “Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein-coupled receptors.” J Biol Chem, vol. 294, no. 36, Sept. 2019, pp. 13218–23. Pubmed, doi:10.1074/jbc.AC119.009848. Full Text
Bond, R. A., and R. J. Lefkowitz. Historical Background and Introduction. Vol. 24, 2006, pp. 1–10. Scopus, doi:10.1002/352760734X.ch1. Full Text
Lefkowitz, R. J., et al. Biochemical mechanisms for regulation of β adrenergic receptors by β adrenergic agonists. Vol. No. 402, 1977, pp. 502–06.
Suomivuori, Carl-Mikael, et al. “Molecular Mechanism of Biased Signaling in a Prototypical G-proteincoupled Receptor.” Biophysical Journal, vol. 118, no. 3, CELL PRESS, 2020, pp. 162A-162A.
Cahill, T. J., et al. “LB987 New insights into gpcr-transducer coupling.” Journal of Investigative Dermatology, vol. 137, no. 10, Elsevier BV, 2017, pp. B10–B10. Crossref, doi:10.1016/j.jid.2017.07.067. Full Text
Lefkowitz, R. J. “Seven transmembrane receptors.” European Biophysics Journal With Biophysics Letters, vol. 46, SPRINGER, 2017, pp. S45–S45.
Smith, J. S., et al. “678 Biased CXCR3 ligands differentially alter allergic contact hypersensitivity and chemotaxis.” Journal of Investigative Dermatology, vol. 137, no. 5, Elsevier BV, 2017, pp. S117–S117. Crossref, doi:10.1016/j.jid.2017.02.701. Full Text
Rein, Lindsay A. M., et al. “beta-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis.” Blood, vol. 126, no. 23, AMER SOC HEMATOLOGY, 2015.
Rein, Lindsay A. M., et al. “Targeting β-arrestin2 Enhances Survival in a Murine Model of Chronic Myeloid Leukemia.” Blood, vol. 122, no. 21, American Society of Hematology, 2013, pp. 857–857. Crossref, doi:10.1182/blood.v122.21.857.857. Full Text
Weiss, Dahlia R., et al. “G-protein coupled receptors in virtual screening: Functional fidelity and selectivity.” Abstracts of Papers of the American Chemical Society, vol. 245, AMER CHEMICAL SOC, 2013.
Shukla, Arun K., et al. “Crystal structure of active Beta-arrestin1 bound to phosphorylated carboxy-terminus of a G protein-coupled receptor.” Faseb Journal, vol. 27, FEDERATION AMER SOC EXP BIOL, 2013.
Maudsley, S., et al. “The Unique Efficacy Profile of a beta-Arrestin Pathway-Selective Parathyroid Hormone Receptor Agonist Revealed by Metabolic Pathways Analysis.” Endocrine Reviews, vol. 31, no. 3, ENDOCRINE SOC, 2010.
Patel, Chetan B., et al. “A Modified beta 1-adrenergic Receptor Demonstrates Bias Towards G Protein Receptor Kinase Phosphorylation.” Circulation, vol. 120, no. 18, LIPPINCOTT WILLIAMS & WILKINS, 2009, pp. S800–01.
Willerson, J. T. “Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.” Circulation, vol. 92, no. 3, 1 Aug. 1995, p. 277. Pubmed, doi:10.1161/01.cir.92.3.277. Full Text