Faculty Profiles

Pei Zhou, Ph.D.
Professor of Chemistry
270 Sands Building, Research Drive, Durham, NC 27710
+1 919 668 6409
(919) 684-8885


Cristillo, AD, Bristow, CC, Torrone, E, Dillon, J-A, Kirkcaldy, RD, Dong, H, Grad, YH, Nicholas, RA, Rice, PA, Lawrence, K, Oldach, D, Shafer, WM, Zhou, P, Wi, TE, Morris, SR, and Klausner, JD. "Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting." Sexually Transmitted Diseases 46.3 (March 2019): e18-e25. Full Text

Lee, M, Zhao, J, Kwak, S-H, Cho, J, Lee, M, Gillespie, RA, Kwon, D-Y, Lee, H, Park, H-J, Wu, Q, Zhou, P, and Hong, J. "Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay." Acs Infectious Diseases (February 5, 2019). Full Text

Wang, T, Yu, Y, Liang, X, Luo, S, He, Z, Sun, Z, Jiang, Y, Omsland, A, Zhou, P, and Song, L. "Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells." Frontiers in Cellular and Infection Microbiology 8 (January 2018): 192-null. Full Text

Liu, Y, Rose, J, Huang, S, Hu, Y, Wu, Q, Wang, D, Li, C, Liu, M, Zhou, P, and Jiang, L. "A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases." Nature Communications 8.1 (December 13, 2017): 2104-null. Full Text

Zhou, P, and Zhao, J. "Structure, inhibition, and regulation of essential lipid A enzymes." Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids 1862.11 (November 2017): 1424-1438. (Review) Full Text Open Access Copy

Zhou, P, and Zhao, J. "Structure, inhibition, and regulation of essential lipid A enzymes." BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1862.11 (November 2017): 1424-1438. Full Text Open Access Copy

Lemaître, N, Liang, X, Najeeb, J, Lee, C-J, Titecat, M, Leteurtre, E, Simonet, M, Toone, EJ, Zhou, P, and Sebbane, F. "Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC." Mbio 8.4 (July 25, 2017). Full Text Open Access Copy

Wu, Q, Fenton, BA, Wojtaszek, JL, and Zhou, P. "Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST)." Chemical Communications (Cambridge, England) 53.61 (July 2017): 8541-8544. Full Text Open Access Copy

Zentella, R, Sui, N, Barnhill, B, Hsieh, W-P, Hu, J, Shabanowitz, J, Boyce, M, Olszewski, NE, Zhou, P, Hunt, DF, and Sun, T-P. "The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA." Nature chemical biology 13.5 (May 2017): 479-485. Full Text Open Access Copy

Titecat, M, Liang, X, Lee, C-J, Charlet, A, Hocquet, D, Lambert, T, Pagès, J-M, Courcol, R, Sebbane, F, Toone, EJ, Zhou, P, and Lemaitre, N. "High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors." The Journal of antimicrobial chemotherapy 71.10 (October 2016): 2874-2882. Full Text Open Access Copy


Coggins, BE, and Zhou, P. "CLEAN." New Developments in NMR. January 1, 2017. 169-219. Full Text

Coggins, BE, and Zhou, P. "Backprojection and Related Methods." New Developments in NMR. January 1, 2017. 119-168. Full Text

Lee, M, Zhao, J, Cho, J, Kwon, D-Y, Zhou, P, and Hong, J. "Synthesis and biological evaluation of sulfonyl piperazine derivatives for LpxH inhibition." 253rd National Meeting of the American-Chemical-Society (ACS) on Advanced Materials, Technologies, Systems, and Processes. April 2, 2017 - April 6, 2017. San Francisco, CA.: AMER CHEMICAL SOC, April 2, 2017.

Chung, BC, Zhao, J, Gillespie, R, Kwon, DY, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis.": Elsevier BV, January 2014. Full Text

Lee, C-J, Liang, X, Park, E, Zeng, D, Swanson, S, Chen, X, Nicholas, RA, Raetz, CRH, Toone, EJ, and Zhou, P. "Structure-activity relationships of diacetylene-based LpxC inhibitors." April 2012.

Young, HE, Metzger, LE, Lee, JK, Stroud, RM, Zhou, P, and Raetz, CRH. "Enzymatic and structural studies of UDP-2,3-diacylglucosamine hydrolysis in lipid A biosynthesis." April 2012.

Zeng, D, Zhou, P, and Raetz, CRH. "Characterization of E. coli mutants resistant to LpxC inhibitors." April 2012.

Greenleaf, AL, Phatnani, HP, Li, M, and Zhou, P. "Structure and CTD phosphorylation pattern-binding specificity of the SRI domain of Set2." March 6, 2006.