Faculty Profiles

Pei Zhou
Professor of Biochemistry
270 Sands Building, Research Drive, Durham, NC 27710
(919) 668-6409
(919) 684-8885



Post-Doct Fellow, Biological Chemistry, Harvard University 1998 - 2001

Ph.D., Harvard University 1998

Ding, Chien-Kuang Cornelia, et al. “MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis.Nature Metabolism, vol. 2, no. 3, Mar. 2020, pp. 270–77. Epmc, doi:10.1038/s42255-020-0181-1. Full Text Open Access Copy

Cho, Jae, et al. “Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics.Proc Natl Acad Sci U S A, vol. 117, no. 8, Feb. 2020, pp. 4109–16. Pubmed, doi:10.1073/pnas.1912876117. Full Text

Ji, Yuhyun, et al. “Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant.Metab Eng, vol. 57, Jan. 2020, pp. 193–202. Pubmed, doi:10.1016/j.ymben.2019.11.009. Full Text Open Access Copy

Wojtaszek, Jessica L., et al. “A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy.Cell, vol. 178, no. 1, June 2019, pp. 152-159.e11. Pubmed, doi:10.1016/j.cell.2019.05.028. Full Text

Zhao, Jinshi, et al. “The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis.Mbio, vol. 10, no. 3, June 2019. Pubmed, doi:10.1128/mBio.00886-19. Full Text Open Access Copy

Yang, Emily J., et al. “NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches.Nat Commun, vol. 10, no. 1, June 2019, p. 2630. Pubmed, doi:10.1038/s41467-019-10517-1. Full Text

Lee, Minhee, et al. “Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay.Acs Infect Dis, vol. 5, no. 4, Apr. 2019, pp. 641–51. Pubmed, doi:10.1021/acsinfecdis.8b00364. Full Text

Cristillo, Anthony D., et al. “Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.Sex Transm Dis, vol. 46, no. 3, Mar. 2019, pp. e18–25. Pubmed, doi:10.1097/OLQ.0000000000000929. Full Text

Wang, Tao, et al. “Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells.Front Cell Infect Microbiol, vol. 8, 2018, p. 192. Pubmed, doi:10.3389/fcimb.2018.00192. Full Text

Liu, Yixiang, et al. “A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases.Nat Commun, vol. 8, no. 1, Dec. 2017, p. 2104. Pubmed, doi:10.1038/s41467-017-02310-9. Full Text


Coggins, B. E., and P. Zhou. “CLEAN.” New Developments in NMR, vol. 2017-January, 2017, pp. 169–219. Scopus, doi:10.1039/9781782628361-00169. Full Text

Coggins, B. E., and P. Zhou. “Backprojection and Related Methods.” New Developments in NMR, vol. 2017-January, 2017, pp. 119–68. Scopus, doi:10.1039/9781782628361-00119. Full Text

An, Jinsu, et al. “The lipid A 1-phosphatase, LpxE, play multiple roles in bacteria envelope biogenesis.” Faseb Journal, vol. 32, no. 1, FEDERATION AMER SOC EXP BIOL, 2018.

Lee, Minhee, et al. “Synthesis and biological evaluation of sulfonyl piperazine derivatives for LpxH inhibition.” Abstracts of Papers of the American Chemical Society, vol. 253, AMER CHEMICAL SOC, 2017.

Zhou, P., et al. “A multi-frequency optoelectronic oscillator based on a single phase-modulator.” Conference on Lasers and Electro Optics Europe  Technical Digest, vol. 2015-August, 2015.

Chung, Ben C., et al. “Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis.” Biophysical Journal, vol. 106, no. 2, Elsevier BV, 2014, pp. 14a-14a. Crossref, doi:10.1016/j.bpj.2013.11.131. Full Text

Masoudi, Ali, et al. “Structural Basis for Acyl-substrate Delivery and Product Release by ACP in the Biosynthesis of Lipid A.” Faseb Journal, vol. 27, FEDERATION AMER SOC EXP BIOL, 2013.

Young, Hayley E., et al. “Enzymatic and structural studies of UDP-2,3-diacylglucosamine hydrolysis in lipid A biosynthesis.” Faseb Journal, vol. 26, 2012.

Zeng, Daina, et al. “Characterization of E. coli mutants resistant to LpxC inhibitors.” Faseb Journal, vol. 26, FEDERATION AMER SOC EXP BIOL, 2012.

Lee, Chul-Jin, et al. “Structure-activity relationships of diacetylene-based LpxC inhibitors.” Faseb Journal, vol. 26, FEDERATION AMER SOC EXP BIOL, 2012.

Greenleaf, A. L., et al. “Structure and CTD phosphorylation pattern-binding specificity of the SRI domain of Set2.” Faseb Journal, vol. 20, no. 4, FEDERATION AMER SOC EXP BIOL, 2006, pp. A467–A467.