Faculty Profiles

Pei Zhou
Professor of Chemistry
270 Sands Building, Research Drive, Durham, NC 27710
(919) 668-6409
(919) 684-8885



Post-Doct Fellow, Biological Chemistry, Harvard University 1998 - 2001

Ph.D., Harvard University 1998

Wojtaszek, Jessica L., et al. “A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy..” Cell, vol. 178, no. 1, June 2019, pp. 152-159.e11. Pubmed, doi:10.1016/j.cell.2019.05.028. Full Text

Zhao, Jinshi, et al. “The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis..” Mbio, vol. 10, no. 3, June 2019. Pubmed, doi:10.1128/mBio.00886-19. Full Text Open Access Copy

Yang, Emily J., et al. “NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches..” Nat Commun, vol. 10, no. 1, June 2019. Pubmed, doi:10.1038/s41467-019-10517-1. Full Text

Lee, Minhee, et al. “Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay..” Acs Infect Dis, vol. 5, no. 4, Apr. 2019, pp. 641–51. Pubmed, doi:10.1021/acsinfecdis.8b00364. Full Text

Cristillo, Anthony D., et al. “Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting..” Sex Transm Dis, vol. 46, no. 3, Mar. 2019, pp. e18–25. Pubmed, doi:10.1097/OLQ.0000000000000929. Full Text

Liu, Yixiang, et al. “A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases..” Nat Commun, vol. 8, no. 1, Dec. 2017. Pubmed, doi:10.1038/s41467-017-02310-9. Full Text

Zhou, Pei, and Jinshi Zhao. “Structure, inhibition, and regulation of essential lipid A enzymes.” Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids, vol. 1862, no. 11, ELSEVIER, Nov. 2017, pp. 1424–38. Wos, doi:10.1016/j.bbalip.2016.11.014. Full Text Open Access Copy

Zhou, Pei, and Jinshi Zhao. “Structure, inhibition, and regulation of essential lipid A enzymes..” Biochim Biophys Acta Mol Cell Biol Lipids, vol. 1862, no. 11, Nov. 2017, pp. 1424–38. Pubmed, doi:10.1016/j.bbalip.2016.11.014. Full Text Open Access Copy

Wu, Qinglin, et al. “Probing the excited-state chemical shifts and exchange parameters by nitrogen-decoupled amide proton chemical exchange saturation transfer (HNdec-CEST)..” Chem Commun (Camb), vol. 53, no. 61, July 2017, pp. 8541–44. Pubmed, doi:10.1039/c7cc05021f. Full Text Open Access Copy


Coggins, B. E., and P. Zhou. “CLEAN.” New Developments in NMR, vol. 2017-January, 2017, pp. 169–219. Scopus, doi:10.1039/9781782628361-00169. Full Text

Coggins, B. E., and P. Zhou. “Backprojection and Related Methods.” New Developments in NMR, vol. 2017-January, 2017, pp. 119–68. Scopus, doi:10.1039/9781782628361-00119. Full Text

An, Jinsu, et al. “The lipid A 1-phosphatase, LpxE, play multiple roles in bacteria envelope biogenesis.” Faseb Journal, vol. 32, no. 1, FEDERATION AMER SOC EXP BIOL, 2018.

Lee, Minhee, et al. “Synthesis and biological evaluation of sulfonyl piperazine derivatives for LpxH inhibition.” Abstracts of Papers of the American Chemical Society, vol. 253, AMER CHEMICAL SOC, 2017.

Zhou, P., et al. “A multi-frequency optoelectronic oscillator based on a single phase-modulator.” Conference on Lasers and Electro Optics Europe  Technical Digest, vol. 2015-August, 2015.

Chung, Ben C., et al. “Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis.” Biophysical Journal, vol. 106, no. 2, Elsevier BV, 2014, pp. 14a-14a. Crossref, doi:10.1016/j.bpj.2013.11.131. Full Text

Masoudi, Ali, et al. “Structural Basis for Acyl-substrate Delivery and Product Release by ACP in the Biosynthesis of Lipid A.” Faseb Journal, vol. 27, FEDERATION AMER SOC EXP BIOL, 2013.

Zeng, Daina, et al. “Characterization of E. coli mutants resistant to LpxC inhibitors.” Faseb Journal, vol. 26, FEDERATION AMER SOC EXP BIOL, 2012.

Lee, Chul-Jin, et al. “Structure-activity relationships of diacetylene-based LpxC inhibitors.” Faseb Journal, vol. 26, FEDERATION AMER SOC EXP BIOL, 2012.

Young, Hayley E., et al. “Enzymatic and structural studies of UDP-2,3-diacylglucosamine hydrolysis in lipid A biosynthesis.” Faseb Journal, vol. 26, 2012.

Greenleaf, A. L., et al. “Structure and CTD phosphorylation pattern-binding specificity of the SRI domain of Set2.” Faseb Journal, vol. 20, no. 4, FEDERATION AMER SOC EXP BIOL, 2006, pp. A467–A467.