Faculty Profiles

Paul L. Modrich
Professor of Chemistry
156A Nanaline H Duke, Durham, NC 27708
(919) 684-2775



Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Spampinato, C, and Modrich, P. "The MutL ATPase is required for mismatch repair." Journal of Biological Chemistry 275.13 (2000): 9863-9869. Full Text

Ma, A-H, Xia, L, Littman, SJ, Swinler, S, Lader, G, Polinkovsky, A, Olechnowicz, J, Kasturi, L, Lutterbaugh, J, Modrich, P, Veigl, ML, Markowitz, SD, and Sedwick, WD. "Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability." Oncogene 19.18 (2000): 2249-2256.

Hoyt, PR, Doktycz, MJ, Modrich, P, Warmack, RJ, and Allison, DP. "Identifying sequence similarities between DNA molecules." Ultramicroscopy 82.1-4 (2000): 237-244. Full Text

Friedman, HS, Pegg, AE, Johnson, SP, Loktionova, NA, Dolan, ME, Modrich, P, Moschel, RC, Struck, R, Brent, TP, Ludeman, S, Bullock, N, Kilborn, C, Keir, S, Dong, Q, Bigner, DD, and Colvin, OM. "Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase." Cancer Chemotherapy and Pharmacology 43.1 (January 1999): 80-85. Full Text

Dong, Q, Johnson, SP, Colvin, OM, Bullock, N, Kilborn, C, Runyon, G, Sullivan, DM, Easton, J, Bigner, DD, Nahta, R, Marks, J, Modrich, P, and Friedman, HS. "Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR)." Cancer Chemotherapy and Pharmacology 43.1 (January 1999): 73-79. Full Text

Blackwell, LJ, Martik, D, Bjornson, KP, Bjornson, ES, and Modrich, P. "Nucleotide-promoted release of hMutSα from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism." Journal of Biological Chemistry 273.48 (1999): 32055-32062. Full Text

Blackwell, LJ, Bjornson, KP, and Modrich, P. "DNA-dependent activation of the hMutSα ATPase." Journal of Biological Chemistry 273.48 (1999): 32049-32054. Full Text

Wright, DJ, Jack, WE, and Modrich, P. "The kinetic mechanism of EcoRI endonuclease." Journal of Biological Chemistry 274.45 (1999): 31896-31902. Full Text

Duckett, DR, Bronstein, SM, Taya, Y, and Modrich, P. "hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage." Proceedings of the National Academy of Sciences of the United States of America 96.22 (1999): 12384-12388. Full Text