Faculty Profiles

Paul L. Modrich
Professor of Chemistry
156A Nanaline H Duke, Durham, NC 27708
(919) 684-2775



Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Modrich, Paul. “Mechanisms in eukaryotic mismatch repair..” The Journal of Biological Chemistry, vol. 281, no. 41, Oct. 2006, pp. 30305–09. Epmc, doi:10.1074/jbc.R600022200. Full Text

York, Sally J., and Paul Modrich. “Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts..” The Journal of Biological Chemistry, vol. 281, no. 32, Aug. 2006, pp. 22674–83. Epmc, doi:10.1074/jbc.M603667200. Full Text

Kadyrov, Farid A., et al. “Endonucleolytic function of MutLalpha in human mismatch repair..” Cell, vol. 126, no. 2, July 2006, pp. 297–308. Pubmed, doi:10.1016/j.cell.2006.05.039. Full Text

Bio FAB Group, P., et al. “Engineering life: building a fab for biology..” Scientific American, vol. 294, no. 6, June 2006, pp. 44–51.

López de Saro, Francisco J., et al. “The beta sliding clamp binds to multiple sites within MutL and MutS..” J Biol Chem, vol. 281, no. 20, May 2006, pp. 14340–49. Pubmed, doi:10.1074/jbc.M601264200. Full Text

Chintagumpala, Murali M., et al. “A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group..” Journal of Neuro Oncology, vol. 77, no. 2, Apr. 2006, pp. 193–98. Epmc, doi:10.1007/s11060-005-9024-x. Full Text

Iyer, Ravi R., et al. “DNA mismatch repair: functions and mechanisms..” Chemical Reviews, vol. 106, no. 2, Feb. 2006, pp. 302–23. Epmc, doi:10.1021/cr0404794. Full Text

Genschel, Jochen, and Paul Modrich. “Analysis of the excision step in human DNA mismatch repair..” Methods in Enzymology, vol. 408, Jan. 2006, pp. 273–84. Epmc, doi:10.1016/s0076-6879(06)08017-7. Full Text

Constantin, Nicoleta, et al. “Human mismatch repair: reconstitution of a nick-directed bidirectional reaction..” The Journal of Biological Chemistry, vol. 280, no. 48, Dec. 2005, pp. 39752–61. Epmc, doi:10.1074/jbc.M509701200. Full Text

Cheng, C. Lynn, et al. “Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft..” Molecular Cancer Therapeutics, vol. 4, no. 9, Sept. 2005, pp. 1364–68. Epmc, doi:10.1158/1535-7163.mct-05-0128. Full Text