Faculty Profiles

Paul L. Modrich
Professor of Chemistry
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Friedman, HS, McLendon, RE, Kerby, T, Dugan, M, Bigner, SH, Henry, AJ, Ashley, DM, Krischer, J, Lovell, S, Rasheed, K, Marchev, F, Seman, AJ, Cokgor, I, Rich, J, Stewart, E, Colvin, OM, Provenzale, JM, Bigner, DD, Haglund, MM, Friedman, AH, and Modrich, PL. "DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 16.12 (December 1998): 3851-3857. Full Text

Veigl, ML, Kasturi, L, Olechnowicz, J, Ma, AH, Lutterbaugh, JD, Periyasamy, S, Li, GM, Drummond, J, Modrich, PL, Sedwick, WD, and Markowitz, SD. "Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers." Proceedings of the National Academy of Sciences of the United States of America 95.15 (July 1998): 8698-8702. Full Text

Lee, SE, Johnson, SP, Hale, LP, Li, J, Bullock, N, Fuchs, H, Friedman, A, McLendon, R, Bigner, DD, Modrich, P, and Friedman, HS. "Analysis of DNA mismatch repair proteins in human medulloblastoma." Clin Cancer Res 4.6 (June 1998): 1415-1419.

Hanley, ML, Elion, GB, Colvin, OM, Modrich, PL, Keir, S, Adams, DJ, Bigner, DD, and Friedman, HS. "Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors." Cancer Chemother Pharmacol 42.6 (1998): 479-482.

Genschel, J, Littman, SJ, Drummond, JT, and Modrich, P. "Isolation of MutSβ from human cells and comparison of the mismatch repair specificities of MutSβ and MutSα." Journal of Biological Chemistry 273.31 (1998): 19895-19901. Full Text

Yamaguchi, M, Dao, V, and Modrich, P. "MutS and MutL activate DNA helicase II in a mismatch-dependent manner." Journal of Biological Chemistry 273.15 (1998): 9197-9201. Full Text

Eshleman, JR, Donover, PS, Littman, SJ, Swinler, SE, Li, G-M, Lutterbaugh, JD, Willson, JKV, Modrich, P, Sedwick, WD, Markowitz, SD, and Veigl, ML. "Increased transversions in a novel mutator colon cancer cell line." Oncogene 16.9 (1998): 1125-1130.

Nicolaides, NC, Littman, SJ, Modrich, P, Kinzler, KW, and Vogelstein, B. "A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype." Molecular and Cellular Biology 18.3 (1998): 1635-1641.

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