Faculty Profiles

Paul L. Modrich
James B. Duke Professor of Biochemistry
156A Nanaline H Duke, Durham, NC 27708
(919) 684-2775



Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Bjornson, KP, Allen, DJ, and Modrich, P. "Modulation of MutS ATP hydrolysis by DNA cofactors." Biochemistry 39.11 (2000): 3176-3183. Full Text

Hoyt, PR, Doktycz, MJ, Modrich, P, Warmack, RJ, and Allison, DP. "Identifying sequence similarities between DNA molecules." Ultramicroscopy 82.1-4 (2000): 237-244. Full Text

Duckett, DR, Bronstein, SM, Taya, Y, and Modrich, P. "hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage." Proceedings of the National Academy of Sciences of the United States of America 96.22 (1999): 12384-12388. Full Text

Friedman, HS, Pegg, AE, Johnson, SP, Loktionova, NA, Dolan, ME, Modrich, P, Moschel, RC, Struck, R, Brent, TP, Ludeman, S, Bullock, N, Kilborn, C, Keir, S, Dong, Q, Bigner, DD, and Colvin, OM. "Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase." Cancer Chemother Pharmacol 43.1 (1999): 80-85. Full Text

Dong, Q, Johnson, SP, Colvin, OM, Bullock, N, Kilborn, C, Runyon, G, Sullivan, DM, Easton, J, Bigner, DD, Nahta, R, Marks, J, Modrich, P, and Friedman, HS. "Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR)." Cancer Chemother Pharmacol 43.1 (1999): 73-79. Full Text

Blackwell, LJ, Martik, D, Bjornson, KP, Bjornson, ES, and Modrich, P. "Nucleotide-promoted release of hMutSα from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism." Journal of Biological Chemistry 273.48 (1999): 32055-32062. Full Text

Blackwell, LJ, Bjornson, KP, and Modrich, P. "DNA-dependent activation of the hMutSα ATPase." Journal of Biological Chemistry 273.48 (1999): 32049-32054. Full Text

Wright, DJ, Jack, WE, and Modrich, P. "The kinetic mechanism of EcoRI endonuclease." Journal of Biological Chemistry 274.45 (1999): 31896-31902. Full Text

Friedman, HS, McLendon, RE, Kerby, T, Dugan, M, Bigner, SH, Henry, AJ, Ashley, DM, Krischer, J, Lovell, S, Rasheed, K, Marchev, F, Seman, AJ, Cokgor, I, Rich, J, Stewart, E, Colvin, OM, Provenzale, JM, Bigner, DD, Haglund, MM, Friedman, AH, and Modrich, PL. "DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma." J Clin Oncol 16.12 (December 1998): 3851-3857. Full Text