Faculty Profiles

Paul L. Modrich
Professor of Chemistry
156A Nanaline H Duke, Durham, NC 27708
(919) 684-2775



Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Spampinato, C., and P. Modrich. “The MutL ATPase is required for mismatch repair..” J Biol Chem, vol. 275, no. 13, Mar. 2000, pp. 9863–69. Pubmed, doi:10.1074/jbc.275.13.9863. Full Text

Bjornson, K. P., et al. “Modulation of MutS ATP hydrolysis by DNA cofactors..” Biochemistry, vol. 39, no. 11, Mar. 2000, pp. 3176–83. Epmc, doi:10.1021/bi992286u. Full Text

Hoyt, P. R., et al. “Identifying sequence similarities between DNA molecules..” Ultramicroscopy, vol. 82, no. 1–4, Feb. 2000, pp. 237–44. Epmc, doi:10.1016/s0304-3991(99)00153-9. Full Text

Wright, D. J., et al. “The kinetic mechanism of EcoRI endonuclease..” J Biol Chem, vol. 274, no. 45, Nov. 1999, pp. 31896–902. Pubmed, doi:10.1074/jbc.274.45.31896. Full Text

Duckett, D. R., et al. “hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage..” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 22, Oct. 1999, pp. 12384–88. Epmc, doi:10.1073/pnas.96.22.12384. Full Text

Littman, S. J., et al. “Repair of large insertion/deletion heterologies in human nuclear extracts is directed by a 5' single-strand break and is independent of the mismatch repair system..” J Biol Chem, vol. 274, no. 11, Mar. 1999, pp. 7474–81. Pubmed, doi:10.1074/jbc.274.11.7474. Full Text

Dong, Q., et al. “Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR)..” Cancer Chemotherapy and Pharmacology, vol. 43, no. 1, Jan. 1999, pp. 73–79. Epmc, doi:10.1007/s002800050865. Full Text

Friedman, H. S., et al. “Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase..” Cancer Chemotherapy and Pharmacology, vol. 43, no. 1, Jan. 1999, pp. 80–85. Epmc, doi:10.1007/s002800050866. Full Text

Friedman, H. S., et al. “DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma..” J Clin Oncol, vol. 16, no. 12, Dec. 1998, pp. 3851–57. Pubmed, doi:10.1200/JCO.1998.16.12.3851. Full Text

Blackwell, L. J., et al. “Nucleotide-promoted release of hMutSalpha from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism..” J Biol Chem, vol. 273, no. 48, Nov. 1998, pp. 32055–62. Pubmed, doi:10.1074/jbc.273.48.32055. Full Text