Faculty Profiles

Paul L. Modrich
Professor of Chemistry
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Koshiji, Minori, et al. “HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression..” Molecular Cell, vol. 17, no. 6, Mar. 2005, pp. 793–803. Epmc, doi:10.1016/j.molcel.2005.02.015. Full Text

Modrich, P. “Early thinking on the nature of mismatch repair.” Dna Repair, vol. 4, no. 1, Jan. 2005, pp. 103–31. Scopus, doi:10.1016/j.dnarep.2004.07.002. Full Text

Lu, A. Lien, et al. “Methyl-directed repair of DNA base-pair mismatches in vitro. 1983..” Dna Repair, vol. 4, no. 1, Jan. 2005, pp. 134–39. Epmc, doi:10.1016/j.dnarep.2004.07.003. Full Text

Martik, Diana, et al. “Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites..” J Biol Chem, vol. 279, no. 27, July 2004, pp. 28402–10. Pubmed, doi:10.1074/jbc.M312108200. Full Text

Dzantiev, Leonid, et al. “A defined human system that supports bidirectional mismatch-provoked excision..” Molecular Cell, vol. 15, no. 1, July 2004, pp. 31–41. Epmc, doi:10.1016/j.molcel.2004.06.016. Full Text

Vilenchik, Maria, et al. “Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90..” Chem Biol, vol. 11, no. 6, June 2004, pp. 787–97. Pubmed, doi:10.1016/j.chembiol.2004.04.008. Full Text

Yang, Qin, et al. “The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase..” Oncogene, vol. 23, no. 21, May 2004, pp. 3749–56. Epmc, doi:10.1038/sj.onc.1207462. Full Text

Baitinger, Celia, et al. “Hydrolytically deficient MutS E694A is defective in the MutL-dependent activation of MutH and in the mismatch-dependent assembly of the MutS.MutL.heteroduplex complex..” The Journal of Biological Chemistry, vol. 278, no. 49, Dec. 2003, pp. 49505–11. Epmc, doi:10.1074/jbc.m308738200. Full Text

Genschel, Jochen, and Paul Modrich. “Mechanism of 5'-directed excision in human mismatch repair..” Molecular Cell, vol. 12, no. 5, Nov. 2003, pp. 1077–86. Epmc, doi:10.1016/s1097-2765(03)00428-3. Full Text

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