Faculty Profiles

Paul L. Modrich
Professor of Chemistry
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Modrich, P. "Mechanisms in eukaryotic mismatch repair." The Journal of Biological Chemistry 281.41 (October 2006): 30305-30309. (Review) Full Text

York, SJ, and Modrich, P. "Mismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts." The Journal of Biological Chemistry 281.32 (August 2006): 22674-22683. Full Text

Chintagumpala, MM, Friedman, HS, Stewart, CF, Kepner, J, McLendon, RE, Modrich, PL, McCluggage, C, Burger, P, Holmes, E, Thompson, S, Rutka, J, Michalski, J, Woo, S, Blaney, SM, Kun, LE, Horowitz, ME, and Pediatric Oncology Group Study, . "A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group." J Neurooncol 77.2 (April 2006): 193-198. Full Text

Iyer, RR, Pluciennik, A, Burdett, V, and Modrich, PL. "DNA mismatch repair: functions and mechanisms." Chemical Reviews 106.2 (February 2006): 302-323. (Review) Full Text

Kadyrov, FA, Dzantiev, L, Constantin, N, and Modrich, P. "Endonucleolytic Function of MutLα in Human Mismatch Repair." Cell 126.2 (2006): 297-308. Full Text

Baker, D, Church, G, Collins, J, Endy, D, Jacobson, J, Keasling, J, Modrich, P, Smolke, C, and Weiss, R. "Engineering life: Building a FAB for biology." Scientific American 294.6 (2006): 44-51.

Saro, FJLD, Marinus, MG, Modrich, P, and O'Donnell, M. "The β sliding clamp binds to multiple sites within MutL and MutS." Journal of Biological Chemistry 281.20 (2006): 14340-14349. Full Text

Genschel, J, and Modrich, P. "Analysis of the Excision Step in Human DNA Mismatch Repair." Methods in Enzymology 408 (2006): 273-284. Full Text

Cheng, CL, Johnson, SP, Keir, ST, Quinn, JA, Ali-Osman, F, Szabo, C, Li, H, Salzman, AL, Dolan, ME, Modrich, P, Bigner, DD, and Friedman, HS. "Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft." Mol Cancer Ther 4.9 (September 2005): 1364-1368. Full Text

Koshiji, M, To, KK-W, Hammer, S, Kumamoto, K, Harris, AL, Modrich, P, and Huang, LE. "HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression." Mol Cell 17.6 (March 18, 2005): 793-803. Full Text

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