Faculty Profiles

Paul L. Modrich
Professor of Chemistry
156A Nanaline H Duke, Durham, NC 27708
(919) 684-2775



Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Liu, Y, Kadyrov, FA, and Modrich, P. "PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro." DNA Repair (Amst) 10.11 (November 10, 2011): 1145-1153. Full Text

Tseng, Q, Orans, J, Hast, MA, Iyer, RR, Changela, A, Modrich, PL, and Beese, LS. "Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ." Acta Crystallographica Section F: Structural Biology and Crystallization Communications 67.Pt 8 (August 2011): 947-952. Full Text

Orans, J, McSweeney, EA, Iyer, RR, Hast, MA, Hellinga, HW, Modrich, P, and Beese, LS. "Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family." Cell 145.2 (April 2011): 212-223. Full Text

Nimonkar, AV, Genschel, J, Kinoshita, E, Polaczek, P, Campbell, JL, Wyman, C, Modrich, P, and Kowalczykowski, SC. "BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair." Genes & Development 25.4 (February 2011): 350-362. Full Text

Pluciennik, A, Dzantiev, L, Iyer, RR, Constantin, N, Kadyrov, FA, and Modrich, P. "PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair." Proceedings of the National Academy of Sciences of the United States of America 107.37 (September 2010): 16066-16071. Full Text

Pillon, MC, Lorenowicz, JJ, Uckelmann, M, Klocko, AD, Mitchell, RR, Chung, YS, Modrich, P, Walker, GC, Simmons, LA, Friedhoff, P, and Guarné, A. "Structure of the endonuclease domain of MutL: unlicensed to cut." Molecular Cell 39.1 (July 2010): 145-151. Full Text

Iyer, RR, Pluciennik, A, Genschel, J, Tsai, M-S, Beese, LS, and Modrich, P. "MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta." The Journal of Biological Chemistry 285.15 (April 2010): 11730-11739. Full Text

Liu, Y, Fang, Y, Shao, H, Lindsey-Boltz, L, Sancar, A, and Modrich, P. "Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway." The Journal of Biological Chemistry 285.8 (February 2010): 5974-5982. Full Text

Oers, JMMV, Roa, S, Werling, U, Liu, Y, Genschel, J, Jr, HH, Sellers, RS, Modrich, P, Scharff, MD, and Edelmann, W. "PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance." Proceedings of the National Academy of Sciences of the United States of America 107.30 (2010): 13384-13389. Full Text

Pluciennik, A, Burdett, V, Lukianova, O, O'Donnell, M, and Modrich, P. "Involvement of the beta clamp in methyl-directed mismatch repair in vitro." The Journal of Biological Chemistry 284.47 (November 2009): 32782-32791. Full Text