Faculty Profiles

Paul L. Modrich
Professor of Chemistry
156A Nanaline H Duke, Durham, NC 27708
(919) 684-2775



Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Sherrer, Shanen M., et al. “The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease.Proc Natl Acad Sci U S A, vol. 115, no. 28, July 2018, pp. 7314–19. Pubmed, doi:10.1073/pnas.1807319115. Full Text

Genschel, Jochen, et al. “Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair.Proc Natl Acad Sci U S A, vol. 114, no. 19, May 2017, pp. 4930–35. Pubmed, doi:10.1073/pnas.1702561114. Full Text

Modrich, Paul. “Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture).Angew Chem Int Ed Engl, vol. 55, no. 30, July 2016, pp. 8490–501. Pubmed, doi:10.1002/anie.201601412. Full Text

Chen, Yu-Tsung Shane, et al. “The C-terminal 20 Amino Acids of Drosophila Topoisomerase 2 Are Required for Binding to a BRCA1 C Terminus (BRCT) Domain-containing Protein, Mus101, and Fidelity of DNA Segregation.J Biol Chem, vol. 291, no. 25, June 2016, pp. 13216–28. Pubmed, doi:10.1074/jbc.M116.721357. Full Text

Qiu, Ruoyi, et al. “MutL traps MutS at a DNA mismatch.Proc Natl Acad Sci U S A, vol. 112, no. 35, Sept. 2015, pp. 10914–19. Pubmed, doi:10.1073/pnas.1505655112. Full Text

Shao, Hongbing, et al. “Hydrolytic function of Exo1 in mammalian mismatch repair.Nucleic Acids Res, vol. 42, no. 11, June 2014, pp. 7104–12. Pubmed, doi:10.1093/nar/gku420. Full Text

Lindsey-Boltz, Laura A., et al. “Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.J Biol Chem, vol. 289, no. 8, Feb. 2014, pp. 5074–82. Pubmed, doi:10.1074/jbc.M113.542787. Full Text

Pluciennik, Anna, et al. “Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLα endonuclease activation.Proc Natl Acad Sci U S A, vol. 110, no. 30, July 2013, pp. 12277–82. Pubmed, doi:10.1073/pnas.1311325110. Full Text

Dowhan, William, et al. “Christian Raetz: scientist and friend extraordinaire.Annu Rev Biochem, vol. 82, 2013, pp. 1–24. Pubmed, doi:10.1146/annurev-biochem-012512-091530. Full Text

Liu, Yiyong, et al. “PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro.Dna Repair (Amst), vol. 10, no. 11, Nov. 2011, pp. 1145–53. Pubmed, doi:10.1016/j.dnarep.2011.08.012. Full Text