Faculty Profiles

Paul L. Modrich
Professor of Chemistry
Office: 
156A Nanaline H Duke, Durham, NC 27708
Phone: 
(919) 684-2775

Overview

Education:

Ph.D., Stanford University 1973

B.S., Massachusetts Institute of Technology 1968

Sherrer, SM, Penland, E, and Modrich, P. "The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease." Proceedings of the National Academy of Sciences of the United States of America 115.28 (July 2018): 7314-7319. Full Text

Genschel, J, Kadyrova, LY, Iyer, RR, Dahal, BK, Kadyrov, FA, and Modrich, P. "Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repair." Proceedings of the National Academy of Sciences of the United States of America 114.19 (May 2017): 4930-4935. Full Text

Modrich, P. "Mechanisms in E. coli and Human Mismatch Repair (Nobel Lecture)." Angewandte Chemie (International Ed. in English) 55.30 (July 2016): 8490-8501. (Review) Full Text

Qiu, R, Sakato, M, Sacho, EJ, Wilkins, H, Zhang, X, Modrich, P, Hingorani, MM, Erie, DA, and Weninger, KR. "MutL traps MutS at a DNA mismatch." Proceedings of the National Academy of Sciences of the United States of America 112.35 (September 2015): 10914-10919. Full Text

Shao, H, Baitinger, C, Soderblom, EJ, Burdett, V, and Modrich, P. "Hydrolytic function of Exo1 in mammalian mismatch repair." Nucleic acids research 42.11 (June 2014): 7104-7112. Full Text

Lindsey-Boltz, LA, Kemp, MG, Reardon, JT, DeRocco, V, Iyer, RR, Modrich, P, and Sancar, A. "Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system." The Journal of Biological Chemistry 289.8 (February 2014): 5074-5082. Full Text

Lindsey-Boltz, LA, Kemp, MG, Reardon, JT, DeRocco, V, Iyer, RR, Modrich, P, and Sancar, A. "Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system." Journal of Biological Chemistry 289.8 (2014): 5074-5082. Full Text

Dowhan, W, Nikaido, H, Stubbe, J, Kozarich, JW, Wickner, WT, Russell, DW, Garrett, TA, Brozek, K, and Modrich, P. "Christian Raetz: scientist and friend extraordinaire." Annual review of biochemistry 82 (2013): 1-24. Full Text

Pluciennik, A, Burdett, V, Baitinger, C, Iyer, RR, Shi, K, and Modrich, P. "Extrahelical (CAG)/(CTG) triplet repeat elements support proliferating cell nuclear antigen loading and MutLa endonuclease activation." Proceedings of the National Academy of Sciences of the United States of America 110.30 (2013): 12277-12282. Full Text

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