Faculty Profiles

Michael J. Therien
William R. Kenan, Jr. Distinguished Professor of Chemistry
Office: 
5330 French Family Science Cen, Durham, NC 27708
Phone: 
(919) 660-1670
Fax: 
(919) 660-1605

Overview

Education:

NIH Postdoctoral Research Fellow, Chemistry, California Institute of Technology 1987 - 1990

Ph.D., University of California - San Diego 1987

B.S., University of St. Andrews (United Kingdom) 1982

Research Areas:
Synthesis, Physical, Biomolecular Structure and Function, Inorganic, Organic, Nanoscience and Materials

Fletcher, James T., and Michael J. Therien. “Strongly coupled porphyrin arrays featuring both pi-cofacial and linear-pi-conjugative interactions.Inorganic Chemistry, vol. 41, no. 2, Jan. 2002, pp. 331–41. Epmc, doi:10.1021/ic010871p. Full Text

Zhang, T. G., and M. J. Therien. “Arylethynyl-derivatized porphyrin chromophores featuring potent electron donors and acceptors for nonlinear optical applications.” American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, vol. 43, no. 2, Jan. 2002, pp. 570–71.

Uyeda, H. T., et al. “Highly conjugated porphyrin-based chromophore systems with unusual electrooptic properties.” American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, vol. 43, no. 2, Jan. 2002, pp. 520–21.

Iovine, P. M., et al. “High-resolution structure and conformational dynamics of rigid, cofacially aligned porphyrin-bridge-quinone systems as determined by NMR spectroscopy and ab initio simulated annealing calculations.Journal of the American Chemical Society, vol. 123, no. 24, June 2001, pp. 5668–79. Epmc, doi:10.1021/ja010023t. Full Text

Yergey, J. A., et al. “In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.Drug Metabolism and Disposition: The Biological Fate of Chemicals, vol. 29, no. 5, May 2001, pp. 638–44.

Angiolillo, P. J., et al. “Trends in triplet excitation delocalization in highly conjugated (porphinato)zinc(II) arrays probed by EPR spectroscopy.” Synthetic Metals, vol. 116, no. 1–3, Jan. 2001, pp. 247–53. Scopus, doi:10.1016/S0379-6779(00)00461-6. Full Text

Fletcher, J. T., and M. J. Therien. “Transition-metal-mediated [2 + 2 + 2] cycloaddition reactions with ethyne-containing porphyrin templates: New routes to cofacial porphyrin structures and facially-functionalized (porphinato)metal species.” Journal of the American Chemical Society, vol. 122, no. 49, Dec. 2000, pp. 12393–94. Scopus, doi:10.1021/ja0001557. Full Text

Nicoll-Griffith, D. A., et al. “Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).Bioorganic & Medicinal Chemistry Letters, vol. 10, no. 23, Dec. 2000, pp. 2683–86. Epmc, doi:10.1016/s0960-894x(00)00538-2. Full Text

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