Faculty Profiles

Michael J. Therien
William R. Kenan, Jr. Professor of Chemistry in Trinity College of Arts and Sciences
5330 French Family Science Cen, Durham, NC 27708
(919) 660-1670
(919) 660-1605



NIH Postdoctoral Research Fellow, Chemistry, California Institute of Technology 1987 - 1990

Ph.D., University of California at San Diego 1987

B.S., University of St. Andrews (Scotland) 1982

Research Areas:
Synthesis, Physical, Biomolecular Structure and Function, Inorganic, Organic, Nanoscience and Materials

Xing, Y, Park, T-H, Venkatramani, R, Keinan, S, Beratan, DN, Therien, MJ, and Borguet, E. "Optimizing single-molecule conductivity of conjugated organic oligomers with carbodithioate linkers." J Am Chem Soc 132.23 (June 16, 2010): 7946-7956. Full Text Open Access Copy

Banerjee, P, Conklin, D, Nanayakkara, S, Park, T-H, Therien, MJ, and Bonnell, DA. "Plasmon-induced electrical conduction in molecular devices." ACS Nano 4.2 (February 23, 2010): 1019-1025. Full Text Open Access Copy

Isabel, E, Bateman, KP, Chauret, N, Cromlish, W, Desmarais, S, Duong, LT, Falgueyret, J-P, Gauthier, JY, Lamontagne, S, Lau, CK, Léger, S, LeRiche, T, Lévesque, J-F, Li, CS, Massé, F, McKay, DJ, Mellon, C, Nicoll-Griffith, DA, Oballa, RM, Percival, MD, Riendeau, D, Robichaud, J, Rodan, GA, Rodan, SB, Seto, C, Thérien, M, Truong, VL, Wesolowski, G, Young, RN, Zamboni, R, and Black, WC. "The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor." Bioorganic & medicinal chemistry letters 20.3 (February 2010): 887-892. Full Text

Hu, X, Xiao, D, Keinan, S, Asselberghs, I, Therien, MJ, Clays, K, Yang, W, and Beratan, DN. "Predicting the frequency dispersion of electronic hyperpolarizabilities on the basis of absorption data and thomas-kuhn sum rules." Journal of Physical Chemistry C 114.5 (2010): 2349-2359. Full Text Open Access Copy

Mey, KD, Clays, K, Therien, MJ, Beratan, DN, and Asselberghs, I. "Analysis of the unusual wavelength dependence of the first hyperpolarizability of porphyrin derivatives." Proceedings of SPIE - The International Society for Optical Engineering 7774 (2010). Full Text

Christian, NA, Benencia, F, Milone, MC, Li, G, Frail, PR, Therien, MJ, Coukos, G, and Hammer, DA. "In vivo dendritic cell tracking using fluorescence lifetime imaging and near-infrared-emissive polymersomes." Mol Imaging Biol 11.3 (May 2009): 167-177. Full Text

Therien, MJ. "Physical chemistry: How to improve your image." Nature 458.7239 (April 9, 2009): 716-717. Full Text