Faculty Profiles

Michael J. Therien
William R. Kenan, Jr. Professor of Chemistry in Trinity College of Arts and Sciences
5330 French Family Science Cen, Durham, NC 27708
(919) 660-1670
(919) 660-1605



NIH Postdoctoral Research Fellow, Chemistry, California Institute of Technology 1987 - 1990

Ph.D., University of California at San Diego 1987

B.S., University of St. Andrews (Scotland) 1982

Research Areas:
Synthesis, Physical, Biomolecular Structure and Function, Inorganic, Organic, Nanoscience and Materials

Flom, SR, Chi, SH, Rosenberg, A, Nayak, A, Duncan, TV, Therien, MJ, Butler, JJ, Montgomery, SR, Beadie, G, and Shirk, JS. "Near IR nonlinear optics of an organic supermolecule." Optics InfoBase Conference Papers (December 1, 2011).

Park, J, Deria, P, and Therien, MJ. "Dynamics and transient absorption spectral signatures of the single-wall carbon nanotube electronically excited triplet state." J Am Chem Soc 133.43 (November 2, 2011): 17156-17159. Full Text

Kamat, NP, Liao, Z, Moses, LE, Rawson, J, Therien, MJ, Dmochowski, IJ, and Hammer, DA. "Sensing membrane stress with near IR-emissive porphyrins." Proc Natl Acad Sci U S A 108.34 (August 23, 2011): 13984-13989. Full Text

Susumu, K, Fisher, JAN, Zheng, J, Beratan, DN, Yodh, AG, and Therien, MJ. "Two-photon absorption properties of proquinoidal D-A-D and A-D-A quadrupolar chromophores." J Phys Chem A 115.22 (June 9, 2011): 5525-5539. Full Text

Guay, D, Beaulieu, C, Belley, M, Crane, SN, DeLuca, J, Gareau, Y, Hamel, M, Henault, M, Hyjazie, H, Kargman, S, Chan, CC, Xu, L, Gordon, R, Li, L, Mamane, Y, Morin, N, Mancini, J, Thérien, M, Tranmer, G, Truong, VL, Wang, Z, and Black, WC. "Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y14 receptor antagonists." Bioorganic & medicinal chemistry letters 21.10 (May 2011): 2832-2835. Full Text

Gauthier, JY, Belley, M, Deschênes, D, Fournier, J-F, Gagné, S, Gareau, Y, Hamel, M, Hénault, M, Hyjazie, H, Kargman, S, Lavallée, G, Levesque, J-F, Li, L, Mamane, Y, Mancini, J, Morin, N, Mulrooney, E, Robichaud, J, Thérien, M, Tranmer, G, Wang, Z, Wu, J, and Black, WC. "The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14." Bioorganic & medicinal chemistry letters 21.10 (May 2011): 2836-2839. Full Text

Lebedeva, NV, Schmidt, RD, Concepcion, JJ, Brennaman, MK, Stanton, IN, Therien, MJ, Meyer, TJ, and Forbes, MDE. "Structural and pH dependence of excited state PCET reactions involving reductive quenching of the MLCT excited state of [RuII(bpy)2(bpz)]2+ by hydroquinones." J Phys Chem A 115.15 (April 21, 2011): 3346-3356. Full Text

Ishizuka, T, Sinks, LE, Song, K, Hung, S-T, Nayak, A, Clays, K, and Therien, MJ. "The roles of molecular structure and effective optical symmetry in evolving dipolar chromophoric building blocks to potent octopolar nonlinear optical chromophores." J Am Chem Soc 133.9 (March 9, 2011): 2884-2896. Full Text

Isabel, E, Mellon, C, Boyd, MJ, Chauret, N, Deschênes, D, Desmarais, S, Falgueyret, J-P, Gauthier, JY, Khougaz, K, Lau, CK, Léger, S, Levorse, DA, Li, CS, Massé, F, Percival, MD, Roy, B, Scheigetz, J, Thérien, M, Truong, VL, Wesolowski, G, Young, RN, Zamboni, R, and Black, WC. "Difluoroethylamines as an amide isostere in inhibitors of cathepsin K." Bioorganic & medicinal chemistry letters 21.3 (February 2011): 920-923. Full Text

Robbins, GP, Lee, D, Katz, JS, Frail, PR, Therien, MJ, Crocker, JC, and Hammer, DA. "Effects of Membrane Rheology on Leuko-polymersome Adhesion to Inflammatory Ligands." Soft Matter 7.2 (January 1, 2011): 769-779. Full Text