Faculty Profiles

Michael J. Therien
William R. Kenan, Jr. Professor of Chemistry in Trinity College of Arts and Sciences
5330 French Family Science Cen, Durham, NC 27708
(919) 660-1670
(919) 660-1605



NIH Postdoctoral Research Fellow, Chemistry, California Institute of Technology 1987 - 1990

Ph.D., University of California at San Diego 1987

B.S., University of St. Andrews (Scotland) 1982

Research Areas:
Synthesis, Physical, Biomolecular Structure and Function, Inorganic, Organic, Nanoscience and Materials

Frenette, R, Hutchinson, JH, Léger, S, Thérien, M, Brideau, C, Chan, CC, Charleson, S, Ethier, D, Guay, J, Jones, TR, McAuliffe, M, Piechuta, H, Riendeau, D, Tagari, P, and Girard, Y. "Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors." Bioorganic & medicinal chemistry letters 9.16 (August 1999): 2391-2396. Full Text

Prasit, P, Wang, Z, Brideau, C, Chan, CC, Charleson, S, Cromlish, W, Ethier, D, Evans, JF, Ford-Hutchinson, AW, Gauthier, JY, Gordon, R, Guay, J, Gresser, M, Kargman, S, Kennedy, B, Leblanc, Y, Léger, S, Mancini, J, O'Neill, GP, Ouellet, M, Percival, MD, Perrier, H, Riendeau, D, Rodger, I, and Zamboni, R. "The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor." Bioorganic & medicinal chemistry letters 9.13 (July 1999): 1773-1778. Full Text

Lindsay, GA, Kolega, RR, Roberts, MJ, Uyeda, HT, Therien, M, and Herman, WN. "Multilayer χ(2) films from porphyrin chromophores by LBK processing." Proceedings of SPIE - The International Society for Optical Engineering 3796 (1999): 299-307.

Hyslop, AG, Kellett, MA, Iovine, PM, and Therien, MJ. "Suzuki porphyrins: New synthons for the fabrication of porphyrin- containing supramolecular assemblies [6]." Journal of the American Chemical Society 120.48 (1998): 12676-12677. Full Text

Kumble, R, Palese, S, Lin, VS-Y, Therien, MJ, and Hochstrasser, RM. "Ultrafast dynamics of highly conjugated porphyrin arrays." Journal of the American Chemical Society 120.44 (1998): 11489-11498. Full Text

Karki, L, Vance, FW, Hupp, JT, LeCours, SM, and Therien, MJ. "Electronic stark effect studies of a porphyrin-based push-pull chromophore displaying a large first hyperpolarizability: State-specific contributions to β." Journal of the American Chemical Society 120.11 (1998): 2606-2611. Full Text

Chan, CC, Panneton, M, Taylor, AM, Therien, M, and Rodger, IW. "A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates." European journal of pharmacology 327.2-3 (May 1997): 221-225. Full Text

Riendeau, D, Percival, MD, Boyce, S, Brideau, C, Charleson, S, Cromlish, W, Ethier, D, Evans, J, Falgueyret, JP, Ford-Hutchinson, AW, Gordon, R, Greig, G, Gresser, M, Guay, J, Kargman, S, Léger, S, Mancini, JA, O'Neill, G, Ouellet, M, Rodger, IW, Thérien, M, Wang, Z, Webb, JK, Wong, E, and Chan, CC. "Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor." British journal of pharmacology 121.1 (May 1997): 105-117. Full Text