Faculty Profiles

Michael J. Therien
William R. Kenan, Jr. Professor of Chemistry in Trinity College of Arts and Sciences
5330 French Family Science Cen, Durham, NC 27708
(919) 660-1670
(919) 660-1605



NIH Postdoctoral Research Fellow, Chemistry, California Institute of Technology 1987 - 1990

Ph.D., University of California at San Diego 1987

B.S., University of St. Andrews (Scotland) 1982

Research Areas:
Synthesis, Physical, Biomolecular Structure and Function, Inorganic, Organic, Nanoscience and Materials

Hyslop, AG, Kellett, MA, Iovine, PM, and Therien, MJ. "Suzuki porphyrins: New synthons for the fabrication of porphyrin- containing supramolecular assemblies [6]." Journal of the American Chemical Society 120.48 (1998): 12676-12677. Full Text

Kumble, R, Palese, S, Lin, VS-Y, Therien, MJ, and Hochstrasser, RM. "Ultrafast dynamics of highly conjugated porphyrin arrays." Journal of the American Chemical Society 120.44 (1998): 11489-11498. Full Text

Karki, L, Vance, FW, Hupp, JT, LeCours, SM, and Therien, MJ. "Electronic stark effect studies of a porphyrin-based push-pull chromophore displaying a large first hyperpolarizability: State-specific contributions to β." Journal of the American Chemical Society 120.11 (1998): 2606-2611. Full Text

Chan, CC, Panneton, M, Taylor, AM, Therien, M, and Rodger, IW. "A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates." European journal of pharmacology 327.2-3 (May 1997): 221-225. Full Text

Riendeau, D, Percival, MD, Boyce, S, Brideau, C, Charleson, S, Cromlish, W, Ethier, D, Evans, J, Falgueyret, JP, Ford-Hutchinson, AW, Gordon, R, Greig, G, Gresser, M, Guay, J, Kargman, S, Léger, S, Mancini, JA, O'Neill, G, Ouellet, M, Rodger, IW, Thérien, M, Wang, Z, Webb, JK, Wong, E, and Chan, CC. "Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor." British Journal of Pharmacology 121.1 (May 1997): 105-117. Full Text

Thérien, M, Brideau, C, Chan, CC, Cromlish, WA, Gauthier, JY, Gordon, R, Greig, G, Kargman, S, Lau, CK, Leblanc, Y, Li, C-S, O'Neill, GP, Riendeau, D, Roy, P, Wang, Z, Xu, L, and Prasit, P. "Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors." Bioorganic & Medicinal Chemistry Letters 7.1 (January 1997): 47-52. Full Text

Roy, P, Leblanc, Y, Ball, RG, Brideau, C, Chan, CC, Chauret, N, Cromlish, W, Ethier, D, Gauthier, JY, Gordon, R, Greig, G, Guay, J, Kargman, S, Lau, CK, O'Neill, G, Silva, J, Thérien, M, van Staden, C, Wong, E, Xu, L, and Prasit, P. "A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles." Bioorganic & Medicinal Chemistry Letters 7.1 (January 1997): 57-62. Full Text

Moore, KT, Horvath, IT, and Therien, MJ. "High-pressure NMR studies of (porphinato)iron-catalyzed isobutane oxidation utilizing dioxygen as the stoichiometric oxidant." Journal of the American Chemical Society 119.7 (1997): 1791-1792. Full Text