Faculty Profiles

Michael J. Therien
William R. Kenan, Jr. Professor of Chemistry in Trinity College of Arts and Sciences
Office: 
5330 French Family Science Cen, Durham, NC 27708
Phone: 
(919) 660-1670
Fax: 
(919) 660-1605

Overview

Education:

NIH Postdoctoral Research Fellow, Chemistry, California Institute of Technology 1987 - 1990

Ph.D., University of California at San Diego 1987

B.S., University of St. Andrews (Scotland) 1982

Research Areas:
Synthesis, Physical, Biomolecular Structure and Function, Inorganic, Organic, Nanoscience and Materials

Kolega, RR, Lindsay, GA, Roberts, MJ, Uyeda, HT, Therien, M, and Herman, WN. "Multilayer Langmuir-Blodgett porphyrin films for second-order non-linear optics." American Chemical Society, Polymer Preprints, Division of Polymer Chemistry 41.1 (2000): 863-864.

Lau, CK, Brideau, C, Chan, CC, Charleson, S, Cromlish, WA, Ethier, D, Gauthier, JY, Gordon, R, Guay, J, Kargman, S, Li, CS, Prasit, P, Riendeau, D, Thérien, M, Visco, DM, and Xu, L. "Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors." Bioorganic & medicinal chemistry letters 9.22 (November 1999): 3187-3192. Full Text

Li, CS, Black, WC, Brideau, C, Chan, CC, Charleson, S, Cromlish, WA, Claveau, D, Gauthier, JY, Gordon, R, Greig, G, Grimm, E, Guay, J, Lau, CK, Riendeau, D, Thérien, M, Visco, DM, Wong, E, Xu, L, and Prasit, P. "A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors." Bioorganic & medicinal chemistry letters 9.22 (November 1999): 3181-3186. Full Text

Chan, CC, Boyce, S, Brideau, C, Charleson, S, Cromlish, W, Ethier, D, Evans, J, Ford-Hutchinson, AW, Forrest, MJ, Gauthier, JY, Gordon, R, Gresser, M, Guay, J, Kargman, S, Kennedy, B, Leblanc, Y, Leger, S, Mancini, J, O'Neill, GP, Ouellet, M, Patrick, D, Percival, MD, Perrier, H, Prasit, P, and Rodger, I. "Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles." The Journal of Pharmacology and Experimental Therapeutics 290.2 (August 1999): 551-560.

Frenette, R, Hutchinson, JH, Léger, S, Thérien, M, Brideau, C, Chan, CC, Charleson, S, Ethier, D, Guay, J, Jones, TR, McAuliffe, M, Piechuta, H, Riendeau, D, Tagari, P, and Girard, Y. "Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors." Bioorganic & medicinal chemistry letters 9.16 (August 1999): 2391-2396. Full Text

Prasit, P, Wang, Z, Brideau, C, Chan, CC, Charleson, S, Cromlish, W, Ethier, D, Evans, JF, Ford-Hutchinson, AW, Gauthier, JY, Gordon, R, Guay, J, Gresser, M, Kargman, S, Kennedy, B, Leblanc, Y, Léger, S, Mancini, J, O'Neill, GP, Ouellet, M, Percival, MD, Perrier, H, Riendeau, D, Rodger, I, and Zamboni, R. "The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor." Bioorganic & Medicinal Chemistry Letters 9.13 (July 1999): 1773-1778. Full Text

Lindsay, GA, Kolega, RR, Roberts, MJ, Uyeda, HT, Therien, M, and Herman, WN. "Multilayer χ(2) films from porphyrin chromophores by LBK processing." Proceedings of SPIE - The International Society for Optical Engineering 3796 (1999): 299-307.

Hyslop, AG, Kellett, MA, Iovine, PM, and Therien, MJ. "Suzuki porphyrins: New synthons for the fabrication of porphyrin- containing supramolecular assemblies [6]." Journal of the American Chemical Society 120.48 (1998): 12676-12677. Full Text

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