Faculty Profiles

Michael C. Fitzgerald
Professor of Chemistry
3222 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1547
(919) 660-1605



Ph.D., University of Wisconsin at Madison 1994

B.S., Davidson College 1989

Research Areas:
Biomolecular Structure and Function, Biological, Analytical

Liu, Fang, and Michael C. Fitzgerald. “Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis..” Journal of Proteome Research, vol. 15, no. 12, Dec. 2016, pp. 4666–74. Epmc, doi:10.1021/acs.jproteome.6b00755. Full Text

Jin, Lorrain, et al. “Targeted Mass Spectrometry-Based Approach for Protein-Ligand Binding Analyses in Complex Biological Mixtures Using a Phenacyl Bromide Modification Strategy..” Analytical Chemistry, vol. 88, no. 22, Nov. 2016, pp. 10987–93. Epmc, doi:10.1021/acs.analchem.6b02658. Full Text

Xu, Yingrong, et al. “Thermodynamic Analysis of the Geldanamycin-Hsp90 Interaction in a Whole Cell Lysate Using a Mass Spectrometry-Based Proteomics Approach..” Journal of the American Society for Mass Spectrometry, vol. 27, no. 10, Oct. 2016, pp. 1670–76. Epmc, doi:10.1007/s13361-016-1457-2. Full Text

Geer Wallace, M. Ariel, et al. “Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements..” J Proteome Res, vol. 15, no. 8, Aug. 2016, pp. 2688–96. Pubmed, doi:10.1021/acs.jproteome.6b00237. Full Text

Geer, M. Ariel, and Michael C. Fitzgerald. “Characterization of the Saccharomyces cerevisiae ATP-Interactome using the iTRAQ-SPROX Technique..” Journal of the American Society for Mass Spectrometry, vol. 27, no. 2, Feb. 2016, pp. 233–43. Epmc, doi:10.1007/s13361-015-1290-z. Full Text

Kwon, Do-Yeon, et al. “Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition..” J Med Chem, vol. 58, no. 19, Oct. 2015, pp. 7659–71. Pubmed, doi:10.1021/acs.jmedchem.5b01220. Full Text

Adhikari, Jagat, et al. “Global analysis of protein folding thermodynamics for disease state characterization..” Journal of Proteome Research, vol. 14, no. 5, May 2015, pp. 2287–97. Epmc, doi:10.1021/acs.jproteome.5b00057. Full Text

Adhikari, Jagat, and Michael C. Fitzgerald. “SILAC-pulse proteolysis: A mass spectrometry-based method for discovery and cross-validation in proteome-wide studies of ligand binding..” Journal of the American Society for Mass Spectrometry, vol. 25, no. 12, Dec. 2014, pp. 2073–83. Epmc, doi:10.1007/s13361-014-0992-y. Full Text

Tran, Duc T., et al. “StableIsotope Labeling with Amino Acids in Cell Culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions..” Molecular & Cellular Proteomics : Mcp, vol. 13, no. 7, July 2014, pp. 1800–13. Epmc, doi:10.1074/mcp.M113.034702. Full Text

Xu, Yingrong, et al. “Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol..” Analytical Chemistry, vol. 86, no. 14, July 2014, pp. 7041–48. Epmc, doi:10.1021/ac501278j. Full Text