Faculty Profiles

Kevin D. Welsher
Assistant Professor of Chemistry
2213 French Science Center, Durham, NC 27705
(919) 660-1509
(919) 660-1605



Postdoctoral Associate, Chemistry, Princeton University 2010 - 2015

Ph.D., Stanford University 2010

B.Sc., Emory University 2005

Research Areas:
Physical, Nanoscience and Materials, Analytical

Lang, Xiaoqi, and Kevin Welsher. “Mapping solvation heterogeneity in live cells by hyperspectral stimulated Raman scattering microscopy.The Journal of Chemical Physics, vol. 152, no. 17, May 2020, p. 174201. Epmc, doi:10.1063/1.5141422. Full Text

Patel, Siddharth, et al. “Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA.Nature Communications, vol. 11, no. 1, Feb. 2020, p. 983. Epmc, doi:10.1038/s41467-020-14527-2. Full Text

Johnson, Courtney, et al. “Continuous focal translation enhances rate of point-scan volumetric microscopy.Optics Express, vol. 27, no. 25, Dec. 2019, pp. 36241–58. Epmc, doi:10.1364/oe.27.036241. Full Text

Hou, Shangguo, and Kevin Welsher. “An Adaptive Real-Time 3D Single Particle Tracking Method for Monitoring Viral First Contacts.Small (Weinheim an Der Bergstrasse, Germany), vol. 15, no. 44, Oct. 2019, p. e1903039. Epmc, doi:10.1002/smll.201903039. Full Text

Hou, Shangguo, et al. “Real-Time 3D Single Particle Tracking: Towards Active Feedback Single Molecule Spectroscopy in Live Cells.Molecules (Basel, Switzerland), vol. 24, no. 15, Aug. 2019. Epmc, doi:10.3390/molecules24152826. Full Text

Hou, Shangguo, and Kevin Welsher. “A Protocol for Real-time 3D Single Particle Tracking.Journal of Visualized Experiments : Jove, no. 131, Jan. 2018. Epmc, doi:10.3791/56711. Full Text

Hou, Shangguo, et al. “Robust real-time 3D single-particle tracking using a dynamically moving laser spot.Optics Letters, vol. 42, no. 12, June 2017, pp. 2390–93. Epmc, doi:10.1364/ol.42.002390. Full Text

Welsher, Kevin, et al. “Discovery of protein- and DNA-imperceptible nanoparticle hard coating using gel-based reaction tuning.Journal of the American Chemical Society, vol. 137, no. 2, Jan. 2015, pp. 580–83. Epmc, doi:10.1021/ja511297d. Full Text

Welsher, Kevin, and Haw Yang. “Imaging the behavior of molecules in biological systems: breaking the 3D speed barrier with 3D multi-resolution microscopy.Faraday Discussions, vol. 184, Jan. 2015, pp. 359–79. Epmc, doi:10.1039/c5fd00090d. Full Text

Welsher, Kevin, and Haw Yang. “Multi-resolution 3D visualization of the early stages of cellular uptake of peptide-coated nanoparticles.Nature Nanotechnology, vol. 9, no. 3, Mar. 2014, pp. 198–203. Epmc, doi:10.1038/nnano.2014.12. Full Text


Johnson, C., and K. Welsher. “Point-scan volumetric imaging rate increased by an optimized linear sparse sampling pattern.” Optics Infobase Conference Papers, vol. Part F144-FiO 2019, 2019. Scopus, doi:10.1364/FIO.2019.JTu4A.101. Full Text