Faculty Profiles

Kenichi Yokoyama
Associate Professor of Chemistry
Office: 
307 Research Drive, Rm 233A Nanaline H Duke Bldg, Durham, NC 27710
Phone: 
(919) 684-8848

Overview

Education:

Ph.D., Tokyo Institute of Technology (Japan) 2008

Pang, Haoran, et al. “Mechanism of Rate Acceleration of Radical C-C Bond Formation Reaction by a Radical SAM GTP 3',8-Cyclase.J Am Chem Soc, vol. 142, no. 20, May 2020, pp. 9314–26. Pubmed, doi:10.1021/jacs.0c01200. Full Text

Chhetri, Abhishek, et al. “Length Specificity and Polymerization Mechanism of (1,3)-β-d-Glucan Synthase in Fungal Cell Wall Biosynthesis.Biochemistry, vol. 59, no. 5, Feb. 2020, pp. 682–93. Pubmed, doi:10.1021/acs.biochem.9b00896. Full Text

Yang, Hao, et al. “The Elusive 5'-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies.J Am Chem Soc, vol. 141, no. 30, July 2019, pp. 12139–46. Pubmed, doi:10.1021/jacs.9b05926. Full Text

Nguyen, Hai P., and Kenichi Yokoyama. “Characterization of Acyl Carrier Protein-Dependent Glycosyltransferase in Mitomycin C Biosynthesis.Biochemistry, vol. 58, no. 25, June 2019, pp. 2804–08. Pubmed, doi:10.1021/acs.biochem.9b00379. Full Text

Yang, Hao, et al. The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by EPR and ENDOR Spectroscopies. June 2019. Epmc, doi:10.26434/chemrxiv.8244596.v1. Full Text

Kuhnert, Eric, et al. “Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases.Environ Microbiol, vol. 20, no. 9, Sept. 2018, pp. 3325–42. Pubmed, doi:10.1111/1462-2920.14333. Full Text

Yokoyama, Kenichi, and Edward A. Lilla. “C-C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products.Nat Prod Rep, vol. 35, no. 7, July 2018, pp. 660–94. Pubmed, doi:10.1039/c8np00006a. Full Text

Byer, Amanda S., et al. “Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis.J Am Chem Soc, vol. 140, no. 28, July 2018, pp. 8634–38. Pubmed, doi:10.1021/jacs.8b04061. Full Text

Yokoyama, Kenichi. “Radical Breakthroughs in Natural Product and Cofactor Biosynthesis.Biochemistry, vol. 57, no. 4, Jan. 2018, pp. 390–402. Pubmed, doi:10.1021/acs.biochem.7b00878. Full Text

Pang, Haoran, and Kenichi Yokoyama. “Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis.Methods Enzymol, vol. 606, 2018, pp. 485–522. Pubmed, doi:10.1016/bs.mie.2018.04.014. Full Text

Pages

Yokoyama, Kenichi. “Radical-Mediated Carbon Skeleton Formation in Cofactor and Natural Product Biosynthesis.” Comprehensive Natural Products III, Elsevier, 2020, pp. 70–95. Crossref, doi:10.1016/b978-0-12-409547-2.14745-6. Full Text

Draelos, Matthew M., and Kenichi Yokoyama. “Biosynthesis and Mechanism of Action of Antifungal Peptidyl Nucleoside Natural Products.” Comprehensive Natural Products III, Elsevier, 2020, pp. 613–41. Crossref, doi:10.1016/b978-0-12-409547-2.14680-3. Full Text

Yokoyama, Kenichi, et al. “Radical-mediated C-C bond formation in natural product and cofactor biosynthesis.” Abstracts of Papers of the American Chemical Society, vol. 258, AMER CHEMICAL SOC, 2019.

McDaniel, Elizabeth, et al. “Insights into the universal radical SAM organometallic intermediate, Omega.” Abstracts of Papers of the American Chemical Society, vol. 257, AMER CHEMICAL SOC, 2019.

Yokoyama, Kenichi, et al. “Capturing a Cryptic Biosynthetic Intermediate Reveals Novel Enzyme Functions in Molybdenum Cofactor Biosynthesis.” Faseb Journal, vol. 30, FEDERATION AMER SOC EXP BIOL, 2016.

Yokoyama, Kenichi, et al. “Capturing a Cryptic Biosynthetic Intermediate Reveals Novel Enzyme Functions in Molybdenum Cofactor Biosynthesis.” Faseb Journal, vol. 30, FEDERATION AMER SOC EXP BIOL, 2016.