Faculty Profiles

Kenichi Yokoyama
Assistant Professor of Chemistry
Office: 
307 Research Drive, Rm 233A Nanaline H Duke Bldg, Durham, NC 27710
Phone: 
(919) 684-8848

Overview

Education:

Ph.D., Tokyo Institute of Technology 2008

Kuhnert, Eric, et al. “Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases..” Environ Microbiol, vol. 20, no. 9, Sept. 2018, pp. 3325–42. Pubmed, doi:10.1111/1462-2920.14333. Full Text

Byer, Amanda S., et al. “Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis..” J Am Chem Soc, vol. 140, no. 28, July 2018, pp. 8634–38. Pubmed, doi:10.1021/jacs.8b04061. Full Text

Yokoyama, Kenichi, and Edward A. Lilla. “C-C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products..” Nat Prod Rep, vol. 35, no. 7, July 2018, pp. 660–94. Pubmed, doi:10.1039/c8np00006a. Full Text

Pang, Haoran, and Kenichi Yokoyama. “Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis..” Methods Enzymol, vol. 606, 2018, pp. 485–522. Pubmed, doi:10.1016/bs.mie.2018.04.014. Full Text

Yokoyama, Kenichi. “Radical Breakthroughs in Natural Product and Cofactor Biosynthesis..” Biochemistry, vol. 57, no. 4, Jan. 2018, pp. 390–402. Epmc, doi:10.1021/acs.biochem.7b00878. Full Text

Ravichandran, Kanchana, et al. “Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase..” Biochemistry, vol. 56, no. 6, Feb. 2017, pp. 856–68. Pubmed, doi:10.1021/acs.biochem.6b01145. Full Text

Lilla, Edward A., and Kenichi Yokoyama. “Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes..” Nat Chem Biol, vol. 12, no. 11, Nov. 2016, pp. 905–07. Pubmed, doi:10.1038/nchembio.2187. Full Text

Chen, Li, et al. “Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity..” Acs Chem Biol, vol. 11, no. 10, Oct. 2016, pp. 2724–33. Pubmed, doi:10.1021/acschembio.6b00604. Full Text

Hover, Bradley M., et al. “Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue..” Biochemistry, vol. 54, no. 49, Dec. 2015, pp. 7229–36. Pubmed, doi:10.1021/acs.biochem.5b00857. Full Text

Yokoyama, Kenichi, and Silke Leimkühler. “The role of FeS clusters for molybdenum cofactor biosynthesis and molybdoenzymes in bacteria..” Biochim Biophys Acta, vol. 1853, no. 6, June 2015, pp. 1335–49. Pubmed, doi:10.1016/j.bbamcr.2014.09.021. Full Text

Pages

Yokoyama, Kenichi, et al. “Capturing a Cryptic Biosynthetic Intermediate Reveals Novel Enzyme Functions in Molybdenum Cofactor Biosynthesis.” Faseb Journal, vol. 30, FEDERATION AMER SOC EXP BIOL, 2016.

Yokoyama, Kenichi, et al. “Capturing a Cryptic Biosynthetic Intermediate Reveals Novel Enzyme Functions in Molybdenum Cofactor Biosynthesis.” Faseb Journal, vol. 30, FEDERATION AMER SOC EXP BIOL, 2016.