Faculty Profiles

Kenichi Yokoyama
Associate Professor of Chemistry
Office: 
307 Research Drive, Rm 233A Nanaline H Duke Bldg, Durham, NC 27710
Phone: 
(919) 684-8848

Overview

Education:

Ph.D., Tokyo Institute of Technology 2008

Yang, Hao, et al. “The Elusive 5'-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies..” J Am Chem Soc, vol. 141, no. 30, July 2019, pp. 12139–46. Pubmed, doi:10.1021/jacs.9b05926. Full Text

Nguyen, Hai P., and Kenichi Yokoyama. “Characterization of Acyl Carrier Protein-Dependent Glycosyltransferase in Mitomycin C Biosynthesis..” Biochemistry, vol. 58, no. 25, June 2019, pp. 2804–08. Pubmed, doi:10.1021/acs.biochem.9b00379. Full Text

Kuhnert, Eric, et al. “Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases..” Environ Microbiol, vol. 20, no. 9, Sept. 2018, pp. 3325–42. Pubmed, doi:10.1111/1462-2920.14333. Full Text

Byer, Amanda S., et al. “Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis..” J Am Chem Soc, vol. 140, no. 28, July 2018, pp. 8634–38. Pubmed, doi:10.1021/jacs.8b04061. Full Text

Yokoyama, Kenichi, and Edward A. Lilla. “C-C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products..” Nat Prod Rep, vol. 35, no. 7, July 2018, pp. 660–94. Pubmed, doi:10.1039/c8np00006a. Full Text

Yokoyama, Kenichi. “Radical Breakthroughs in Natural Product and Cofactor Biosynthesis..” Biochemistry, vol. 57, no. 4, Jan. 2018, pp. 390–402. Epmc, doi:10.1021/acs.biochem.7b00878. Full Text

Pang, Haoran, and Kenichi Yokoyama. “Lessons From the Studies of a CC Bond Forming Radical SAM Enzyme in Molybdenum Cofactor Biosynthesis..” Methods Enzymol, vol. 606, 2018, pp. 485–522. Pubmed, doi:10.1016/bs.mie.2018.04.014. Full Text

Ravichandran, Kanchana, et al. “Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase..” Biochemistry, vol. 56, no. 6, Feb. 2017, pp. 856–68. Pubmed, doi:10.1021/acs.biochem.6b01145. Full Text

Lilla, Edward A., and Kenichi Yokoyama. “Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes..” Nat Chem Biol, vol. 12, no. 11, Nov. 2016, pp. 905–07. Pubmed, doi:10.1038/nchembio.2187. Full Text

Chen, Li, et al. “Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity..” Acs Chem Biol, vol. 11, no. 10, Oct. 2016, pp. 2724–33. Pubmed, doi:10.1021/acschembio.6b00604. Full Text

Pages

Yokoyama, Kenichi, et al. “Capturing a Cryptic Biosynthetic Intermediate Reveals Novel Enzyme Functions in Molybdenum Cofactor Biosynthesis.” Faseb Journal, vol. 30, FEDERATION AMER SOC EXP BIOL, 2016.

Yokoyama, Kenichi, et al. “Capturing a Cryptic Biosynthetic Intermediate Reveals Novel Enzyme Functions in Molybdenum Cofactor Biosynthesis.” Faseb Journal, vol. 30, FEDERATION AMER SOC EXP BIOL, 2016.