Ph.D., Massachusetts Institute of Technology 2000
B.A., Wellesley College 1995
Wang, Q, and Franz, KJ. "Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress." Bioorganic & Medicinal Chemistry 26.22 (December 2018): 5962-5972. Full Text
Bakthavatsalam, S, Sleeper, ML, Dharani, A, George, DJ, Zhang, T, and Franz, KJ. "Leveraging γ-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells." Angewandte Chemie (International Ed. in English) 57.39 (September 2018): 12780-12784. Full Text
Zaengle-Barone, JM, Jackson, AC, Besse, DM, Becken, B, Arshad, M, Seed, PC, and Franz, KJ. "Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria." ACS infectious diseases (March 20, 2018). Full Text
Hall, KC, Franks, AT, McAtee, RC, Wang, MS, Lu, VI, and Franz, KJ. "Metal-binding hydrazone photoswitches for visible light reactivity and variable relaxation kinetics." Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 16.11 (November 2017): 1604-1612. Full Text
Wang, Q, and Franz, KJ. "The hydrolytic susceptibility of prochelator BSIH in aqueous solutions." Bioorganic & Medicinal Chemistry Letters 27.17 (September 2017): 4165-4170. Full Text
Conklin, SE, Bridgman, EC, Su, Q, Riggs-Gelasco, P, Haas, KL, and Franz, KJ. "Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans." Biochemistry 56.32 (August 2017): 4244-4255. Full Text Open Access Copy
Helsel, ME, White, EJ, Razvi, SZA, Alies, B, and Franz, KJ. "Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans." Metallomics : Integrated Biometal Science 9.1 (January 2017): 69-81. Full Text
Wang, Q, and Franz, KJ. "Stimulus-Responsive Prochelators for Manipulating Cellular Metals." Accounts of Chemical Research 49.11 (November 2016): 2468-2477. Full Text
Sansee, A, Meksawangwong, S, Chainok, K, Franz, KJ, Gál, M, Pålsson, L-O, Puniyan, W, Traiphol, R, Pal, R, and Kielar, F. "Novel aminoalkyl tris-cyclometalated iridium complexes as cellular stains." Dalton Transactions (Cambridge, England : 2003) 45.43 (November 2016): 17420-17430. Full Text
Hašková, P, Jansová, H, Bureš, J, Macháček, M, Jirkovská, A, Franz, KJ, Kovaříková, P, and Šimůnek, T. "Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury." Toxicology 371 (September 2016): 17-28. Full Text
Wang, Q, and Franz, KJ. "Detection of Metal Ions, Anions and Small Molecules Using Metal Complexes." Inorganic Chemical Biology: Principles, Techniques and Applications. June 23, 2014. 233-274. Full Text
Franz, KJ. "Chemical Approaches for Manipulating Microbial Metals." July 2017.
Franz, KJ. "Manipulating metals at the host-pathogen interface." March 16, 2014.
Franks, A, Helsel, M, and Franz, KJ. "Development of stimulus-responsive metal chelation with novel fluorescence reporting." April 7, 2013.
Franz, KJ. "Optimizing prochelators to bind metal ions in response to disease-associated stimuli[p]." March 25, 2012.
Folk, DS, Torosian, J, and Franz, KJ. "BACE activated prochelator mediates A beta-Cu toxicity in an Alzheimer's disease cell model." March 25, 2012.
Zielonka, J, Kielar, F, Sikora, A, Franz, KJ, and Kalyanaraman, B. "Dual Antioxidant Activity of Boronate-Based Prochelators: Scavenging Peroxynitrite and Metal Ion Chelation." November 1, 2011. Full Text
Franz, KJ. "Design of prochelators that bind cellular metal ions in response to diverse stimuli." August 28, 2011.
Franz, KJ, and Haas, KL. "Insights into the role of histidine in Ctr1-dependent copper uptake." August 22, 2010.
Hyman, LM, and Franz, KJ. "Development of triggereable chelating agents as probes for metal-induced oxidative stress." August 22, 2010.