Faculty Profiles

Katherine J. Franz
Alexander F. Hehmeyer Professor of Chemistry and Department Chair
2103 French Science Center, 124 Science Drive, Durham, NC 27708
(919) 660-1541



Ph.D., Massachusetts Institute of Technology 2000

B.A., Wellesley College 1995

Research Areas:
Biomolecular Structure and Function, Inorganic

Franz, KJ. "Clawing back: Broadening the notion of metal chelators in medicine." Current Opinion in Chemical Biology 17.2 (2013): 143-149. Full Text

Kielar, F, Wang, Q, Boyle, PD, and Franz, KJ. "A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal binding." Inorganica Chimica Acta 393 (December 2012): 294-303. Full Text

Folk, DS, Torosian, JC, Hwang, S, McCafferty, DG, and Franz, KJ. "Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe." Angew Chem Int Ed Engl 51.43 (October 22, 2012): 10795-10799. Full Text

Hyman, LM, and Franz, KJ. "Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols." Coordination Chemistry Reviews 256.19-20 (October 2012): 2333-2356. Full Text

Kielar, F, Helsel, ME, Wang, Q, and Franz, KJ. "Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation." Metallomics : Integrated Biometal Science 4.9 (August 2012): 899-909. Full Text

Rubino, JT, and Franz, KJ. "Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function." Journal of Inorganic Biochemistry 107.1 (February 2012): 129-143. (Review) Full Text

Franz, KJ. "Application of inorganic chemistry for non-cancer therapeutics." Dalton Transactions 41.21 (2012): 6333-6334. Full Text

Leed, MGD, Wolkow, N, Pham, DM, Daniel, CL, Dunaief, JL, and Franz, KJ. "Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress." J Inorg Biochem 105.9 (September 2011): 1161-1172. Full Text

Haas, KL, Putterman, AB, White, DR, Thiele, DJ, and Franz, KJ. "Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1." Journal of the American Chemical Society 133.12 (March 4, 2011): 4427-4437. Full Text