Faculty Profiles

Katherine J. Franz
Professor in the Department of Chemistry
Office: 
2103 French Science Center, 124 Science Drive, Durham, NC 27708
Phone: 
(919) 660-1541

Overview

Education:

Ph.D., Massachusetts Institute of Technology 2000

B.A., Wellesley College 1995

Research Areas:
Biomolecular Structure and Function, Inorganic

Franz, Katherine J., and Nils Metzler-Nolte. “Introduction: Metals in Medicine.Chemical Reviews, vol. 119, no. 2, Jan. 2019, pp. 727–29. Epmc, doi:10.1021/acs.chemrev.8b00685. Full Text

Franz, Katherine J. “Metallomics: Emerging Investigators 2019.Metallomics : Integrated Biometal Science, vol. 11, no. 1, Jan. 2019, pp. 9–14. Epmc, doi:10.1039/c8mt90047g. Full Text

Wang, Qin, and Katherine J. Franz. “Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress.Bioorganic & Medicinal Chemistry, vol. 26, no. 22, Dec. 2018, pp. 5962–72. Epmc, doi:10.1016/j.bmc.2018.11.004. Full Text

Bakthavatsalam, Subha, et al. “Leveraging γ-Glutamyl Transferase To Direct Cytotoxicity of Copper Dithiocarbamates against Prostate Cancer Cells.Angew Chem Int Ed Engl, vol. 57, no. 39, Sept. 2018, pp. 12780–84. Pubmed, doi:10.1002/anie.201807582. Full Text

Zaengle-Barone, Jacqueline M., et al. “Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria.Acs Infect Dis, vol. 4, no. 6, June 2018, pp. 1019–29. Pubmed, doi:10.1021/acsinfecdis.8b00037. Full Text

Hall, Kacey C., et al. “Metal-binding hydrazone photoswitches for visible light reactivity and variable relaxation kinetics.Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology, vol. 16, no. 11, Nov. 2017, pp. 1604–12. Epmc, doi:10.1039/c7pp00173h. Full Text

Wang, Qin, and Katherine J. Franz. “The hydrolytic susceptibility of prochelator BSIH in aqueous solutions.Bioorganic & Medicinal Chemistry Letters, vol. 27, no. 17, Sept. 2017, pp. 4165–70. Epmc, doi:10.1016/j.bmcl.2017.07.019. Full Text

Conklin, Steven E., et al. “Specific Histidine Residues Confer Histatin Peptides with Copper-Dependent Activity against Candida albicans.Biochemistry, vol. 56, no. 32, Aug. 2017, pp. 4244–55. Epmc, doi:10.1021/acs.biochem.7b00348. Full Text Open Access Copy

Helsel, Marian E., et al. “Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans.Metallomics : Integrated Biometal Science, vol. 9, no. 1, Jan. 2017, pp. 69–81. Epmc, doi:10.1039/c6mt00172f. Full Text

Wang, Qin, and Katherine J. Franz. “Stimulus-Responsive Prochelators for Manipulating Cellular Metals.Accounts of Chemical Research, vol. 49, no. 11, Nov. 2016, pp. 2468–77. Epmc, doi:10.1021/acs.accounts.6b00380. Full Text

Pages

Rubino, Jeffrey T., and Katherine J. Franz. “Characterization of thioether-only Cu(I) binding by Ctr1 methionine motifs.” Abstracts of Papers of the American Chemical Society, vol. 238, AMER CHEMICAL SOC, 2009.

Dickens, Marina G., et al. “Synthesis of masked bidentate and hexadentate iron chelators designed to reduce oxidative stress.” Abstracts of Papers of the American Chemical Society, vol. 238, AMER CHEMICAL SOC, 2009.

Haas, Kathryn L., et al. “Spectroscopic studies of N-terminal Cu(II)- and Cu(I)-binding hCtrl model peptides.” Abstracts of Papers of the American Chemical Society, vol. 238, AMER CHEMICAL SOC, 2009.

Franz, Katherine J. “Design of triggerable ligands for altering metal coordination in biological settings.” Abstracts of Papers of the American Chemical Society, vol. 238, AMER CHEMICAL SOC, 2009.

Ciesienski, Katie L., et al. “Photolabile ligand for light-activated release of caged copper.” Abstracts of Papers of the American Chemical Society, vol. 237, AMER CHEMICAL SOC, 2009.

Hunt, Lynne M., and Kathenine J. Franz. “INOR 273-Development of prochelators as probes of iron-induced oxidative stress.” Abstracts of Papers of the American Chemical Society, vol. 235, AMER CHEMICAL SOC, 2008.

Crider, Sarah E., and Katherine J. Franz. “INOR 277-Interactions of cisplatin and methionine-rich peptide domains of the human high-affinity copper transporter Ctr1.” Abstracts of Papers of the American Chemical Society, vol. 235, AMER CHEMICAL SOC, 2008.

Franz, Katherine J., and Louise K. Charkoudian. “INOR 916-A pro-chelator strategy for inhibiting metal-catalyzed oxidative stress.” Abstracts of Papers of the American Chemical Society, vol. 234, AMER CHEMICAL SOC, 2007.

Charkoudian, Louise K., and Katherine J. Franz. “INOR 614-Development of iron chelators triggered by reactive oxygen species.” Abstracts of Papers of the American Chemical Society, vol. 232, AMER CHEMICAL SOC, 2006.

Franz, Katherine J., et al. “INOR 1011-Copper(I) binding by methionine-rich domains of copper transport proteins.” Abstracts of Papers of the American Chemical Society, vol. 232, AMER CHEMICAL SOC, 2006.

Pages