Faculty Profiles

Katherine J. Franz
Alexander F. Hehmeyer Professor of Chemistry
Office: 
2103 French Science Center, 124 Science Drive, Durham, NC 27708
Phone: 
(919) 660-1541

Overview

Education:

Ph.D., Massachusetts Institute of Technology 2000

B.A., Wellesley College 1995

Research Areas:
Biomolecular Structure and Function, Inorganic

Franz, Katherine J. “Clawing back: broadening the notion of metal chelators in medicine..” Current Opinion in Chemical Biology, vol. 17, no. 2, Apr. 2013, pp. 143–49. Epmc, doi:10.1016/j.cbpa.2012.12.021. Full Text

Kumbhar, Anupa A., et al. “Light uncages a copper complex to induce nonapoptotic cell death..” Chemical Communications (Cambridge, England), vol. 49, no. 24, Mar. 2013, pp. 2460–62. Epmc, doi:10.1039/c3cc38927h. Full Text

Franz, K. J. “Clawing back: Broadening the notion of metal chelators in medicine.” Current Opinion in Chemical Biology, vol. 17, no. 2, 2013, pp. 143–49. Scival, doi:10.1016/j.cbpa.2012.12.021. Full Text

Kielar, Filip, et al. “A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal binding..” Inorganica Chimica Acta, vol. 393, Dec. 2012, pp. 294–303. Epmc, doi:10.1016/j.ica.2012.06.011. Full Text

Hyman, Lynne M., and Katherine J. Franz. “Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols..” Coordination Chemistry Reviews, vol. 256, no. 19–20, Oct. 2012, pp. 2333–56. Epmc, doi:10.1016/j.ccr.2012.03.009. Full Text

Folk, Drew S., et al. “Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe..” Angewandte Chemie (International Ed. in English), vol. 51, no. 43, Oct. 2012, pp. 10795–99. Epmc, doi:10.1002/anie.201206673. Full Text

Kielar, Filip, et al. “Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation..” Metallomics : Integrated Biometal Science, vol. 4, no. 9, Aug. 2012, pp. 899–909. Epmc, doi:10.1039/c2mt20069d. Full Text

Franz, Katherine J. “Application of inorganic chemistry for non-cancer therapeutics..” Dalton Transactions (Cambridge, England : 2003), vol. 41, no. 21, June 2012, pp. 6333–34. Epmc, doi:10.1039/c2dt90061k. Full Text

Rubino, Jeffrey T., and Katherine J. Franz. “Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function..” Journal of Inorganic Biochemistry, vol. 107, no. 1, Feb. 2012, pp. 129–43. Epmc, doi:10.1016/j.jinorgbio.2011.11.024. Full Text

Hyman, Lynne M., and Katherine J. Franz. “A Cell-Permeable Fluorescent Prochelator Responds to Hydrogen Peroxide and Metal Ions by Decreasing Fluorescence..” Inorganica Chimica Acta, vol. 380, Jan. 2012, pp. 125–34. Epmc, doi:10.1016/j.ica.2011.11.056. Full Text

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